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dc.creatorCarroll, Ann L.
dc.creatorDamme, Katherine S. F.
dc.creatorAlloy, Lauren B.
dc.creatorBart, Corinne P.
dc.creatorNg, Tommy Ho-Yee
dc.creatorTitone, Madison
dc.creatorChein, Jason
dc.creatorCichocki, Anna C.
dc.creatorArmstrong, Casey C.
dc.creatorNusslock, Robin
dc.identifier.citationAnn L. Carroll, Katherine S.F. Damme, Lauren B. Alloy, Corinne P. Bart, Tommy H. Ng, Madison K. Titone, Jason Chein, Anna C. Cichocki, Casey C. Armstrong, Robin Nusslock, Risk for bipolar spectrum disorders associated with positive urgency and orbitofrontal cortical grey matter volume, NeuroImage: Clinical, Volume 36, 2022, 103225, ISSN 2213-1582,
dc.description.abstractBipolar spectrum disorders (BSDs) are associated with reward hypersensitivity, impulsivity, and structural abnormalities within the brain’s reward system. Using a behavioral high-risk study design based on reward sensitivity, this paper had two primary objectives: 1) investigate whether elevated positive urgency, the tendency to act rashly when experiencing extreme positive affect, is a risk for or correlate of BSDs, and 2) examine the nature of the relationship between positive urgency and grey matter volume in fronto-striatal reward regions, among individuals at differential risk for BSD. Young adults (ages 18–28) screened to be moderately reward sensitive (MReward; N = 42), highly reward sensitive (HReward; N = 48), or highly reward sensitive with a lifetime BSD (HReward + BSD; N = 32) completed a structural MRI scan and the positive urgency subscale of the UPPS-P scale. Positive urgency scores varied with BSD risk (MReward < HReward < HReward + BSD; ps≤0.05), and positive urgency interacted with BSD risk group in predicting lateral OFC volume (p <.001). Specifically, the MReward group showed a negative relationship between positive urgency and lateral OFC volume. By contrast, there was no relationship between positive urgency and lateral OFC grey matter volume among the HReward and HReward + BSD groups. The results suggest that heightened trait positive urgency is a pre-existing vulnerability for BSD that worsens with illness onset, and there is a distinct relationship between positive urgency and lateral OFC volume among individuals at high versus low risk for BSD. These findings have implications for understanding the expression and development of impulsivity in BSDs.
dc.format.extent9 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartNeuroImage: Clinical, Vol. 36
dc.rightsAttribution CC BY
dc.subjectBipolar spectrum disorder (BSD)
dc.subjectPositive urgency
dc.subjectGrey matter volume
dc.subjectOrbitofrontal cortex (OFC)
dc.titleRisk for bipolar spectrum disorders associated with positive urgency and orbitofrontal cortical grey matter volume
dc.type.genreJournal article
dc.description.departmentPsychology and Neuroscience
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeTemple University. College of Liberal Arts
dc.temple.creatorAlloy, Lauren B.
dc.temple.creatorBart, Corinne P.
dc.temple.creatorNg, Tommy H.
dc.temple.creatorTitone, Madison K.
dc.temple.creatorChein, Jason

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