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  • Breast Reconstruction Systematic Review Search Strategy

    Patel, Sameer; Vega, Kevin; Araya, Sthefano; Perez, Chris; Near, Christian; Gubara, Sarah; Siegel, Jacob; Alonso, Gabriel; Nace, Travis (2024-04-23)
    To identify studies to include or consider for this [review type] review, the review team worked with a librarian (TN]) to develop detailed search strategies for each database. The PRISMA-S extension was followed for search reporting. The librarian (TN) developed the search for PubMed (NLM) and translated the search for every database searched. The PubMed (NLM) search strategy was reviewed by the research team to check for accuracy and term relevancy. All final searches were peer-reviewed by another librarian following the Peer Review of Electronic Search Strategies (PRESS checklist). The search was limited to English language only. The databases included in this search are PubMed (NLM), Embase (Elsevier), Cochrane Central Register of Controlled Trials (Wiley), Web of Science Core Collection (Clarivate Analytics), and HealthSTAR (Ovid) using a combination of keywords and subject headings. A grey literature search included Clinical Trials Registry (https://classic.clinicaltrials.gov/), WHO ICTRP (https://trialsearch.who.int/), TRIP Pro Database (tripdatabase.com), and MedRxiv (https://www.medrxiv.org/). All final searches were performed on April 12, 2024 by the librarian and were fully reported on April 18, 2024. The full search strategies as reported by the librarian are provided in Appendix (___). A summary of the search results: PubMed (NLM) from 1809 to 4/12/2024 (200 Results) Embase (Elsevier) from 1974 to 4/12/2024 (458 Results) Cochrane Central Register of Controlled Trials (Wiley) from inception to 4/12/2024 (26 Results) Web of Science Core Collection (Clarivate Analytics) from 1900 to 4/12/2024 (177 Results) HealthSTAR (Ovid) from 1975 to 4/12/2024 (198 results) Clinical Trials Registry (https://classic.clinicaltrials.gov/) from inception to 4/12/2024 (74 Results) WHO ICTRP (https://trialsearch.who.int/) 1900 to 4/12/2024 (4 Results) TRIP Pro Database from 1867 to 4/12/2024 (53 Results) MedRxiv (https://www.medrxiv.org/) from inception to 4/12/2024 (5 results) The search resulted in 1,195 studies. 567 duplicate studies were found and omitted by the librarian (TN) using EndNote 20 following the Wichor Bramer duplicate identification strategy. This resulted in 591 records to screen from databases or registers and 58 records to screen from other methods (websites), resulting in a total of 628 records. Studies were screened by title and abstract by two blinded and independent reviewers. If a tiebreaker was needed, a third reviewer was called in. This process was repeated for full text article screening and article selection.
  • Psychopathological Impact of Stressful Workplace Environments

    Shah, Mansi; Bounyarith, Tiara; O’Hanlon, Kaitlyn (Temple University. Grey Matters, 2023-05-09)
  • Chronic Traumatic Encephalopathy: The Aftermath of Playing America's Favorite Sport

    Shah, Mansi; Roberts, Peyton; Rahman, Ridwana (Temple University. Grey Matters, 2023-05-09)
    Millions of children share the dream of becoming a professional football player in the National Football League (NFL), but it is a dream that very few achieve. Some will earn the chance to play in high school, a smaller percentage will be able to play at the collegiate level, and only the best will be chosen to play in the NFL. The athletes who beat the odds and make it to the NFL do not make it by accident. To play in the NFL requires endless years of hard work, dedication, and sacrifice. Players give up time with friends and family, holidays, and endure grueling training schedules all to play in the league. The boisterous noise from the crowd, the rush of adrenaline on game day, and the financial stability that comes with being a professional athlete in the NFL is enticing. But, what if the very thing you have been striving for since you were a kid puts you and your future at risk? What if the toll that the beloved game puts on your body is irreversible, leaving you to suffer the detriments of the violent sport long after you exit the field for the final time? This was unfortunately a reality for many former football players who suffered from Chronic Traumatic Encephalopathy (CTE). Chronic traumatic encephalopathy (CTE) is a progressive and fatal brain disease associated with repeated traumatic brain injuries (TBIs), including concussions and repeated blows to the head [1]. The types of injuries that lead to CTE are common in American Football [2]. This article will explain the neurological underpinnings of CTE, its psychological and behavioral effects, and how future bioengineering may help identify CTE antemortem.
  • More than Just a Headache

    Shah, Mansi; Martin, Georgia; Schneider, Daniel (Temple University. Grey Matters, 2023-05-09)
    Despite the high prevalence of fifty percent among the global population, the common headache is often underestimated, under-recognized, and under-treated [1]. Different sensations associated with headaches have been experienced by most individuals throughout their lifetime; many report having various degrees of pressure that may be described as throbbing, constant, sharp, or dull [2]. While headaches can be easily dismissed by healthcare providers, it is essential to differentiate how common symptoms may be a sign of underlying issues. In order to understand how the symptoms of a headache are commonly misdiagnosed and may indicate potential underlying physiological issues, it is important to analyze the types of headaches, symptoms, potential effects on the brain over time, and treatment.
  • Gene-Based Therapies for Neurodegenerative Diseases

    Shah, Mansi; Nakahara, Kate; Becker, Claire (Temple University. Grey Matters, 2023-05-09)
    While infectious viruses have had devastating effects throughout history, recently developed virus-based biotechnologies have the potential to revolutionize treatment of genetic diseases. Specifically, viruses have been vital in the advancement of gene therapy [1]. Gene-based therapy treats diseases by altering the body at the cellular level with the potential to deliver longer-lasting and more personalized impacts than traditional drug-based therapies, making it an appealing route for “achieving permanent correction” [2],[3]. Gene therapy corrects mutated genes that have undergone alterations in their DNA sequence through the delivery of genetic material into cells [4]. A gene mutation occurs when there is a change in a DNA sequence that causes the sequence to be different from what is expected. Gene mutations can be characterized as hereditary or acquired mutations. Hereditary mutations are inherited from parents, while acquired mutations are created at a particular time in a person’s life [5]. A tool known as a vector can act as a vessel for the genetic material to aid the delivery process [4]. Alongside plasmids and nanostructures, viruses can act as a type of viral vector to improve the efficiency of gene therapy [6]. Given the incurable nature of neurodegenerative diseases, which are characterized by the gradual loss of function and death of nerve cells, gene therapy is quickly emerging as a helpful method for improving their management [7]. This article will investigate the efficacy of applying gene-based therapies to the diagnosis and treatment of neurodegenerative diseases and the methodology available today.

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