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    Minimizing Cell Death During the Extrusion Bioprinting of Gelatin-Alginate Bioinks

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    Genre
    Research project
    Date
    2021
    Author
    Kraynak, Jack
    Advisor
    Danowsky, Joseph
    Department
    Bioengineering
    Subject
    Bioprint
    Bioprinting
    Bioink
    Bioprinted scaffold
    Cell death
    Cell death bioprinting
    Extrusion bioprinting
    Gelatin-alginate bioink
    Hydrogel bioprinting
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/6299
    
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    DOI
    http://dx.doi.org/10.34944/dspace/6281
    Abstract
    This proposal seeks to minimize cell death while extrusion bioprinting with a gelatin-alginate bioink. Extrusion bioprinting was chosen over other types of bioprinting due to its accessibility and cost to researchers. Two different nozzles, cylindrical and conical, are examined to determine a mechanical aspect of extrusion bioprinting that can be modified to greatly minimize the cell death of bioprinted scaffolds. Gelatin-algiate bioinks can vary in concentration, and this concentration was also varied as a candidate solution to obtain the optimal concentration while maintaining a high cell survivability. The conical nozzle was chosen as the optimal printing nozzle with low shear stress, low cell damage, and highest cell viability. The 4% gelatin 5% alginate bioink was chosen as the optimal bioink concentration with optimal viscosity and high cell viability. Together, the use of this nozzle and this concentration bioink will greatly minimize the cell damage that occurs during extrusion bioprinting, boosting the quality of extrusion printing, and making it all-around more viable. Extrusion bioprinting, due to its improved cell death percentage, will be utilized more often by researchers – this will potentially accelerate the innovation of bioprinting as an overall technology towards the final goal of bioprinting a fully functioning organ.
    Description
    This research project was completed as part of the Honors Technical Communication by Design course.
    Citation to related work
    Livingstone Undergraduate Research Awards website: https://sites.temple.edu/livingstone/2021-livingstone-undergraduate-research-award-in-stem/
    ADA compliance
    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
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