Loading...
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations
Vargas, E Yarov-Yarovoy, V Khalili-Araghi, F Catterall, WA Klein, ML Tarek, M Lindahl, E Schulten, K Perozo, E Bezanilla, F
Vargas, E
Yarov-Yarovoy, V
Khalili-Araghi, F
Catterall, WA
Klein, ML
Tarek, M
Lindahl, E
Schulten, K
Perozo, E
Bezanilla, F
Citations
Altmetric:
Genre
Journal Article
Date
2012-01-01
Advisor
Committee member
Group
Department
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
10.1085/jgp.201210873
Abstract
Developing an understanding of the mechanism of voltage-gated ion channels in molecular terms requires knowledge of the structure of the active and resting conformations. Although the active-state conformation is known from x-ray structures, an atomic resolution structure of a voltage-dependent ion channel in the resting state is not currently available. This has motivated various efforts at using computational modeling methods and molecular dynamics (MD) simulations to provide the missing information. A comparison of recent computational results reveals an emerging consensus on voltage-dependent gating from computational modeling and MD simulations. This progress is highlighted in the broad context of preexisting work about voltage-gated channels. © 2012 Vargas et al.
Description
Citation
Citation to related work
Rockefeller University Press
Has part
Journal of General Physiology
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu