Host genetics and population structure effects on parasitic disease
Genre
Journal ArticleDate
2012-01-01Author
Williams-Blangero, SCriscione, CD
VandeBerg, JL
Correa-Oliveira, R
Williams, KD
Subedi, J
Kent, JW
Williams, J
Kumar, S
Blangero, J
Subject
population structuregenetics of infectious disease susceptibility
intestinal worms
Chagas disease
Permanent link to this record
http://hdl.handle.net/20.500.12613/5484
Metadata
Show full item recordDOI
10.1098/rstb.2011.0296Abstract
Host genetic factors exert significant influences on differential susceptibility to many infectious diseases. In addition, population structure of both host and parasite may influence disease distribution patterns. In this study, we assess the effects of population structure on infectious disease in two populations in which host genetic factors influencing susceptibility to parasitic disease have been extensively studied. The first population is the Jirel population of eastern Nepal that has been the subject of research on the determinants of differential susceptibility to soil-transmitted helminth infections. The second group is a Brazilian population residing in an area endemic for Trypanosoma cruzi infection that has been assessed for genetic influences on differential disease progression in Chagas disease. For measures of Ascaris worm burden, within-population host genetic effects are generally more important than host population structure factors in determining patterns of infectious disease. No significant influences of population structure on measures associated with progression of cardiac disease in individuals who were seropositive for T. cruzi infection were found.Citation to related work
The Royal SocietyHas part
Philosophical Transactions of the Royal Society B: Biological SciencesADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.eduae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.34944/dspace/5466