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dc.creatorHenry, KA
dc.creatorFagliano, J
dc.creatorJordan, HM
dc.creatorRechtman, L
dc.creatorKaye, WE
dc.date.accessioned2021-01-31T16:10:59Z
dc.date.available2021-01-31T16:10:59Z
dc.date.issued2015-01-01
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5245
dc.identifier.other26041711 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5263
dc.description.abstract© 2015 The Author. Few analyses in the United States have examined geographic variation and socioeconomic disparities in amyotrophic lateral sclerosis (ALS) incidence, because of lack of population-based incidence data. In this analysis, we used population-based ALS data to identify whether ALS incidence clusters geographically and to determine whether ALS risk varies by area-based socioeconomic status (SES). This study included 493 incident ALS cases diagnosed (via El Escorial criteria) in New Jersey between 2009 and 2011. Geographic variation and clustering of ALS incidence was assessed using a spatial scan statistic and Bayesian geoadditive models. Poisson regression was used to estimate the associations between ALS risk and SES based on census-tract median income while controlling for age, sex, and race. ALS incidence varied across and within counties, but there were no statistically significant geographic clusters. SES was associated with ALS incidence. After adjustment for age, sex, and race, the relative risk of ALS was significantly higher (relative risk (RR) = 1.37, 95% confidence interval (CI): 1.02, 1.82) in the highest income quartile than in the lowest. The relative risk of ALS was significantly lower among blacks (RR = 0.57, 95% CI: 0.39, 0.83) and Asians (RR = 0.63, 95% CI: 0.41, 0.97) than among whites. Our findings suggest that ALS incidence in New Jersey appears to be associated with SES and race.
dc.format.extent512-519
dc.language.isoen
dc.relation.haspartAmerican Journal of Epidemiology
dc.relation.isreferencedbyOxford University Press (OUP)
dc.rightsCC BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectamyotrophic lateral sclerosis
dc.subjectdisease mapping
dc.subjectspatial analysis
dc.titleGeographic Variation of Amyotrophic Lateral Sclerosis Incidence in New Jersey, 2009-2011
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.1093/aje/kwv095
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-31T16:10:56Z
refterms.dateFOA2021-01-31T16:11:00Z


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