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dc.creatorValentino, RJ
dc.creatorBangasser, DA
dc.date.accessioned2021-01-29T16:58:30Z
dc.date.available2021-01-29T16:58:30Z
dc.date.issued2016-01-01
dc.identifier.issn1294-8322
dc.identifier.issn1958-5969
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5138
dc.identifier.other28179810 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5156
dc.description.abstract© 2016 AICH-Servier Research Group. All rights reserved. The recognition that there are fundamental biological sex differences that extend beyond those that define sexual behavior and reproductive function has inspired the drive toward inclusion of both sexes in research design. This is supported by an underlying clinical rationale that studying both sexes is necessary to elucidate pathophysiology and develop treatments for the entire population. However, at a more basic level, sex differences, like genetic differences, can be exploited to better understand biology. Here, we discuss how sex differences at the molecular level of cell signaling and protein trafficking are amplified to create a state of vulnerability that under the right conditions can result in symptoms of neuropsychiatric disease. Although this dialogue focuses on the specific example of corticotropin- releasing factor, the potential for analogous sex differences in signaling and/or trafficking of receptors for other neuromodulators has broad biological and therapeutic implications.
dc.format.extent385-393
dc.language.isoen
dc.relation.haspartDialogues in Clinical Neuroscience
dc.relation.isreferencedbyServier International
dc.rightsCC BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectamygdala
dc.subjectarousal
dc.subjectbeta-arrestin
dc.subjectcorticotropin-releasing factor
dc.subjectG-GTP
dc.subjectbinding protein
dc.subjectlocus coeruleus
dc.subjectnorepinephrine
dc.subjectstress
dc.titleSex-biased cellular signaling: Molecular basis for sex differences in neuropsychiatric diseases
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.31887/dcns.2016.18.4/rvalentino
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-01-29T16:58:25Z
refterms.dateFOA2021-01-29T16:58:31Z


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