Evolution of gag and gp41 in Patients Receiving Ritonavir-Boosted Protease Inhibitors
dc.creator | Manasa, J | |
dc.creator | Varghese, V | |
dc.creator | Pond, SLK | |
dc.creator | Rhee, SY | |
dc.creator | Tzou, PL | |
dc.creator | Fessel, WJ | |
dc.creator | Jang, KS | |
dc.creator | White, E | |
dc.creator | Rögnvaldsson, T | |
dc.creator | Katzenstein, DA | |
dc.creator | Shafer, RW | |
dc.date.accessioned | 2021-01-28T21:39:35Z | |
dc.date.available | 2021-01-28T21:39:35Z | |
dc.date.issued | 2017-12-01 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.doi | http://dx.doi.org/10.34944/dspace/5091 | |
dc.identifier.other | 28912582 (pubmed) | |
dc.identifier.uri | http://hdl.handle.net/20.500.12613/5109 | |
dc.description.abstract | © 2017 The Author(s). Several groups have proposed that genotypic determinants in gag and the gp41 cytoplasmic domain (gp41-CD) reduce protease inhibitor (PI) susceptibility without PI-resistance mutations in protease. However, no gag and gp41-CD mutations definitively responsible for reduced PI susceptibility have been identified in individuals with virological failure (VF) while receiving a boosted PI (PI/r)-containing regimen. To identify gag and gp41 mutations under selective PI pressure, we sequenced gag and/or gp41 in 61 individuals with VF on a PI/r (n = 40) or NNRTI (n = 20) containing regimen. We quantified nonsynonymous and synonymous changes in both genes and identified sites exhibiting signal for directional or diversifying selection. We also used published gag and gp41 polymorphism data to highlight mutations displaying a high selection index, defined as changing from a conserved to an uncommon amino acid. Many amino acid mutations developed in gag and in gp41-CD in both the PI-A nd NNRTI-treated groups. However, in neither gene, were there discernable differences between the two groups in overall numbers of mutations, mutations displaying evidence of diversifying or directional selection, or mutations with a high selection index. If gag and/or gp41 encode PI-resistance mutations, they may not be confined to consistent mutations at a few sites. | |
dc.format.extent | 11559- | |
dc.language.iso | en | |
dc.relation.haspart | Scientific Reports | |
dc.relation.isreferencedby | Springer Science and Business Media LLC | |
dc.rights | CC BY | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Adult | |
dc.subject | Evolution, Molecular | |
dc.subject | Female | |
dc.subject | Genotype | |
dc.subject | HIV Envelope Protein gp41 | |
dc.subject | HIV Infections | |
dc.subject | HIV Protease Inhibitors | |
dc.subject | HIV-1 | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Mutation | |
dc.subject | Ritonavir | |
dc.subject | Selection, Genetic | |
dc.subject | Sequence Analysis, DNA | |
dc.subject | Young Adult | |
dc.subject | gag Gene Products, Human Immunodeficiency Virus | |
dc.title | Evolution of gag and gp41 in Patients Receiving Ritonavir-Boosted Protease Inhibitors | |
dc.type | Article | |
dc.type.genre | Journal Article | |
dc.relation.doi | 10.1038/s41598-017-11893-8 | |
dc.ada.note | For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu | |
dc.creator.orcid | Pond, Sergei L. Kosakovsky|0000-0003-4817-4029 | |
dc.date.updated | 2021-01-28T21:39:31Z | |
refterms.dateFOA | 2021-01-28T21:39:35Z |