Thumbnail Image
Item

Hepatitis B x (HBx) as a Component of a Functional Cure for Chronic Hepatitis B

; 
Arzumanyan, Alla
; 
Spector, Ira
; 
Medhat, Arvin
Citations
Altmetric:
Genre
Journal article
Date
2022-09-07
Advisor
Committee member
Group
Department
Biology
Subject
Functional cure
 Hepatitis B x antigen
 Pathogenesis
 Chronic liver disease
Permanent link to this record
http://hdl.handle.net/20.500.12613/9912
Collections
Faculty/Researcher Works
Show all metadata
Files
Thumbnail Image
FeitelsonEtAl-JournalArticle-2022-09.pdf
Adobe PDF, 1.3 MB
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.3390/biomedicines10092210
Abstract
Patients who are carriers of the hepatitis B virus (HBV) are at high risk of chronic liver disease (CLD) which proceeds from hepatitis, to fibrosis, cirrhosis and to hepatocellular carcinoma (HCC). The hepatitis B-encoded X antigen, HBx, promotes virus gene expression and replication, protects infected hepatocytes from immunological destruction, and promotes the development of CLD and HCC. For virus replication, HBx regulates covalently closed circular (ccc) HBV DNA transcription, while for CLD, HBx triggers cellular oxidative stress, in part, by triggering mitochondrial damage that stimulates innate immunity. Constitutive activation of NF-κB by HBx transcriptionally activates pro-inflammatory genes, resulting in hepatocellular destruction, regeneration, and increased integration of the HBx gene into the host genome. NF-κB is also hepatoprotective, which sustains the survival of infected cells. Multiple therapeutic approaches include direct-acting anti-viral compounds and immune-stimulating drugs, but functional cures were not achieved, in part, because none were yet devised to target HBx. In addition, many patients with cirrhosis or HCC have little or no virus replication, but continue to express HBx from integrated templates, suggesting that HBx contributes to the pathogenesis of CLD. Blocking HBx activity will, therefore, impact multiple aspects of the host–virus relationship that are relevant to achieving a functional cure.
Description
Citation
Feitelson, M.A.; Arzumanyan, A.; Spector, I.; Medhat, A. Hepatitis B x (HBx) as a Component of a Functional Cure for Chronic Hepatitis B. Biomedicines 2022, 10, 2210. https://doi.org/10.3390/biomedicines10092210
Citation to related work
MDPI
Has part
Biomedicines, Vol. 10, Iss. 9
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
Embedded videos