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Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants
Liu, Jinbiao Wang, Xu Wang, Peng Meng, Fengzhen Khan, Adil I. Saribas, A. Sami Padhiar, Nigam H. McCluskey, Elizabeth Shah, Sahil
Liu, Jinbiao
Wang, Xu
Wang, Peng
Meng, Fengzhen
Khan, Adil I.
Saribas, A. Sami
Padhiar, Nigam H.
McCluskey, Elizabeth
Shah, Sahil
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Pre-print
Date
2021-05-31
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Pathology and Laboratory Medicine
Neurology
Neurology
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https://doi.org/10.1101/2021.05.31.445871
Abstract
Both Pfizer-BNT162b2 and Moderna-mRNA-1273 vaccines can elicit an effective immune response against SARS-CoV-2 infection. However, the elicited serum antibody levels vary substantially and longitudinally decrease after vaccination. We examined the correlation of vaccination-induced IgG levels and neutralization titers against newly emerged variants remains and demonstrate a significant reduction of neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351) in Pfizer or Moderna vaccined sera. There was a significant and positive correlation between serum IgG levels and ID50 titers for not only SARS-CoV-2 WT but also the variants. These findings indicate that a high level of anti-spike IgG may offer better protection against infection from SARS-CoV-2 and its variants. Therefore, it is necessary to longitudinally monitor specific serum IgG level for evaluating the protective efficacy of the vaccines against SARS-CoV-2 and its new variants.
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Jinbiao Liu, Brittany H Bodnar, Xu Wang, Peng Wang, Fengzhen Meng, Adil I Khan, A Sami Saribas, Nigam H Padhiar, Elizabeth McCluskey, Sahil Shah, Jin Jun Luo, Wen-Hui Hu, Wen-Zhe Ho. Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants. bioRxiv 2021.05.31.445871; doi: https://doi.org/10.1101/2021.05.31.445871
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