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    Epithelial Ovarian Cancer: The Role of Cell Cycle Genes in the Different Histotypes

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    Name:
    Epithelial ovarian cancer the ...
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    Genre
    Journal Article
    Date
    2008-02-14
    Author
    D'Andrilli, Giuseppina
    Giordano, Antonio
    Bovicelli, Alessandro
    Subject
    Cell cycle deregulation
    cancer therapy
    ovarian carcinoma histotypes
    ovarian malignancy
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/5610
    
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    DOI
    10.2174/1874189400802010007
    Abstract
    Cancer is frequently considered to be a disease of the cell cycle; alterations in different families of cell cycle regulators cooperate in tumor development. Molecular analysis of human tumors has shown that cell cycle regulators are frequently mutated in human neoplasms, which underscores how important the maintenance of cell cycle commitment is in the prevention of human cancer. The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes which display a range of abnormalities with potential usefulness as markers of evolution or treatment response in epithelial ovarian cancer. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary. We sought to focus our attention on the genes involved in the development of tumors arising from the ovarian epithelium, which are the most common types of ovarian malignancies.
    Citation to related work
    Bentham Science Publishers Ltd.
    Has part
    The Open Clinical Cancer Journal
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    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/5592
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