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    The retinoblastoma family: Twins or distant cousins?

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    Name:
    The retinoblastoma family twins ...
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    Genre
    Review
    Journal
    Date
    2002-09-23
    Author
    Claudio, PP
    Tonini, T
    Giordano, A
    Subject
    Animals
    Apoptosis
    Cell Differentiation
    Chromosome Mapping
    Evolution, Molecular
    Genes, Retinoblastoma
    Humans
    Mice
    Neovascularization, Physiologic
    Nuclear Proteins
    Phosphoproteins
    Phylogeny
    Plants
    Proteins
    Rats
    Retinoblastoma Protein
    Retinoblastoma-Like Protein p107
    Retinoblastoma-Like Protein p130
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    Permanent link to this record
    http://hdl.handle.net/20.500.12613/5089
    
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    DOI
    10.1186/gb-2002-3-9-reviews3012
    Abstract
    The destiny of a cell - whether it undergoes division, differentiation or death - results from an intricate balance of many regulators, including oncoproteins, tumor-suppressor proteins and cell-cycle-associated proteins. One of the better-studied tumor suppressors is the retinoblastoma protein, known as pRb or p105. Two recently identified proteins, pRb2/p130 and p107, show structural and functional similarities to pRb, and these proteins and their orthologs make up the retinoblastoma (Rb) family. Members of the family have been found in animals and plants, and a related protein is known in the alga Chlamydomonas. Members of the Rb family are bound and inactivated by viral proteins and, in turn, bind cellular transcription factors and repress their function, and can also form complexes with cyclins and cyclin-dependent kinases and with histone deacetylases. The are found in the nucleus and their subnuclear localization depends on binding to the nuclear matrix. Members of the family form part of a signal-transduction pathway called the Rb pathway, which is important in cell-cycle regulation and have roles in growth suppression, differentiation and apoptosis in different organisms and cell types.
    Citation to related work
    Springer Science and Business Media LLC
    Has part
    Genome Biology
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/5071
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