2022-04-222022-04-222022-02-15Roberts HA, Clark DA, Kalina C, Sherman C, Brislin S, Heitzeg MM, et al. (2022) To vax or not to vax: Predictors of anti-vax attitudes and COVID-19 vaccine hesitancy prior to widespread vaccine availability. PLoS ONE 17(2): e0264019. https://doi.org/10.1371/journal.pone.02640191932-6203http://dx.doi.org/10.34944/dspace/7540http://hdl.handle.net/20.500.12613/7562The novel coronavirus (COVID-19) is a highly contagious disease responsible for millions of deaths worldwide. Effective vaccines against COVID-19 are now available, however, an extreme form of vaccine hesitancy known as anti-vax attitudes challenge vaccine acceptance and distribution efforts. To understand these anti-vax attitudes and their associated psychological characteristics, we examined several predictors of vaccine hesitancy for COVID-19 and anti-vax attitudes generally. We surveyed 1004 adults (M = 47.0 years, SD = 17.1 years, range 18–98 years) in September-October 2020 across the United States (51% female, 49% male; 76.5% White, 23.5% non-White), prior to widespread availability of the COVID-19 vaccines. Attitudes toward vaccinations were influenced by a variety of factors, especially political attitudes. We should therefore anticipate and attempt to mitigate these challenges to achieving widespread vaccination to reduce the spread of COVID-19 and other communicable diseases.19 pagesengAttribution CC BYhttp://creativecommons.org/licenses/by/4.0/COVID 19VaccinesPsychological attitudesSocial mediaVaccination and immunizationPandemicsEducational attainmentMMR vaccineTo vax or not to vax: Predictors of anti-vax attitudes and COVID-19 vaccine hesitancy prior to widespread vaccine availabilityText