2020-11-112020-11-112020-09-120012-3692http://dx.doi.org/10.34944/dspace/4135http://hdl.handle.net/20.500.12613/4153Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.12 pagesengAll Rights ReservedCOVID-19EtoposideText