Patil, Chetan A.Lemay, Michel A.2021-01-062021-01-062019http://hdl.handle.net/20.500.12613/4625Research has shown that photo-biomodulation of neurons with near-infrared (NIR) light can stimulate their regeneration, and thus various research groups have developed devices that emit NIR light transcranially (through the skull) to stimulate neural growth in the brain in an effort to treat neurological diseases such as Multiple Sclerosis (MS) and Alzheimer’s. However, it is not clear that clinical device designs illuminate cells in the brain with similar parameters as those shown effective for neuro-regeneration in pre-clinical work. This project employed computational modeling and simulations to assess the effect of device design parameters on transcranial light propagation, in order to optimize illumination of brain tissue and cells and thus ultimately improve clinical results of transcranial NIR-emitting devices for neuro-regeneration. Specifically, this project consisted of the development of two computational models for transcranial NIR-emitting devices and the evaluation of three device parameters: wavelength, photon number, and power density, on transcranial NIR light propagation.65 pagesengIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.http://rightsstatements.org/vocab/InC/1.0/Nervous system--DiseasesRegenerative medicineMonte Carlo methodText