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Changes in Neuronal Activity Post- Neonatal Brachial Plexus Avulsion Injury
Kadiyala, Nisha Naidu
Kadiyala, Nisha Naidu
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2025-06
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Bioengineering
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https://doi.org/10.34944/kznc-ne84
Abstract
Neonatal brachial plexus root avulsion (NBPRA) is a severe childbirth injury that can disrupt spinal cord activity. In this study, we investigated how NBPRA affects neuronal activity across different depths of the spinal cord ipsilaterally (injured side) and contralaterally (control/uninjured side), before and after avulsion. Using multielectrode array (MEA), spike sorting, and principal component analysis (PCA), we analyzed the neuronal activity of six piglets to identify changes in active spike units and firing rates before and after avulsion. Our results showed that there is no significant difference between the number of active spike units or firing frequency between the ipsilateral or contralateral side before and after injury. However, we did see a significant difference in firing frequency between ipsilateral and contralateral sides after avulsion, suggesting that the two sides respond differently to sustained injuries. By characterizing the neuronal responses, we aim to understand the mechanisms by which spinal networks adapt to avulsion and identify key neuronal populations involved in these changes. These results provide insights into the immediate neural adaptations following neonatal BPRA and create a foundation for developing strategies that can help mitigate the effects of such injuries.
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