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A Review of Myositis-Associated Interstitial Lung Disease
Kumar, Raagni Cichelli, Kimberly Brent, Lawrence H.
Kumar, Raagni
Cichelli, Kimberly
Brent, Lawrence H.
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Journal article
Date
2024-07-11
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Rheumatology
Internal Medicine
Internal Medicine
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DOI
https://doi.org/10.3390/jcm13144055
Abstract
There is a well-established relationship between different subsets of idiopathic inflammatory myopathies (IIMs, myositis) and interstitial lung disease (ILD), with lung complications sometimes presenting prior to myopathic manifestations. The subtypes of myositis include those that are strongly associated with ILD, such as polymyositis (PM) and dermatomyositis (DM). Research has shown that in certain patients, these can then be further divided into subtypes using myositis-specific antibodies (MSAs), which are specific for myositis, and myositis-associated antibodies (MAAs), which can be found in myositis in overlap syndromes with other connective tissue diseases (CTDs). Notably, certain MSAs and MAAs are associated with ILD in patients with myositis. The clinical presentations of ILD in patients with myositis can vary widely and can be insidious in onset and difficult to diagnose. As ILD can progress rapidly in some cases, it is essential that clinicians are able to identify and diagnose ILD in patients with myositis. For this reason, the aim of this review is to highlight the clinical features, diagnostic criteria, important histopathologic, laboratory, and radiographic features, and treatment modalities for those patients with myositis-associated ILD.
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Citation
Kannappan, R.; Kumar, R.; Cichelli, K.; Brent, L.H. A Review of Myositis-Associated Interstitial Lung Disease. J. Clin. Med. 2024, 13, 4055. https://doi.org/10.3390/jcm13144055
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Journal of Clinical Medicine, Vol. 13, No. 14
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