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Intravenous cangrelor infusion for the treatment of traumatic intracranial internal carotid artery dissection: illustrative case
Graves, Erin K. M. Vallejo, Meghan Quach, Erin T.
Graves, Erin K. M.
Vallejo, Meghan
Quach, Erin T.
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Journal article
Date
2025-06-30
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Committee member
Department
Neurosurgery
Pharmacy
Pharmacy
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DOI
https://doi.org/10.3171/CASE2559
Abstract
BACKGROUND
Antithrombotic initiation in patients with traumatic arterial dissections is weighed against the risk of bleeding complications. Cangrelor is a direct P2Y12 receptor blocker with rapid onset and reversibility. As such, its usage in polytrauma cases such as these, in which patients have both an elevated bleeding risk and an acute need for thromboembolic prevention, is advantageous.
OBSERVATIONS
This case details cangrelor usage in a patient with a traumatic left cavernous internal carotid artery dissection as well as acute intracranial hemorrhage and other systemic injuries. No hemorrhagic or thromboembolic complications occurred during cangrelor therapy, which was eventually transitioned to oral aspirin. Outpatient follow-up angiography revealed successful healing of the carotid dissection.
LESSONS
The authors present a case demonstrating the clinical utility of cangrelor therapy to treat traumatic arterial dissections and prevent thrombus formation while also maintaining the ability to achieve rapid reversal if bleeding were to occur or urgent surgical procedures were needed.
Description
Citation
Rao, A. N., Graves, E. K. M., Vallejo, M., & Quach, E. T. (2025). Intravenous cangrelor infusion for the treatment of traumatic intracranial internal carotid artery dissection: illustrative case. Journal of Neurosurgery: Case Lessons, 9(26), CASE2559. https://doi.org/10.3171/CASE2559
Citation to related work
Journal of Neurosurgery Publishing Group (JNSPG)
Has part
Journal of Neurosurgery: Case Lessons, Vol. 9, No. 26
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