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Lessons from autopsy: Topographical variability of atherosclerosis plaques
Faa, Gavino Cau, Riccardo Ravarino, Alberto Canino, Andrea Van Eyken, Peter Fraschini, Matteo Suri, Jasjit S. Saba, Luca
Faa, Gavino
Cau, Riccardo
Ravarino, Alberto
Canino, Andrea
Van Eyken, Peter
Fraschini, Matteo
Suri, Jasjit S.
Saba, Luca
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Journal article
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2024-04-01
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Biology
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https://doi.org/10.1177/22799036241249659
Abstract
Atherosclerosis is a complex disease characterized by the accumulation of plaques in arterial walls. Understanding its pathogenesis remains incomplete, with factors like inflammation, oxidative stress, and hypertension playing critical roles. The disease exhibits preferential localization of plaques, with variability observed even within the same individual. Genetic, environmental, and lifestyle factors contribute to its heterogeneity. Histological plaque phenotypes vary widely, prompting classification schemes focusing on systemic and local factors deteriorating fibrous caps. Recent research highlights differences in plaque histology among arterial systems, suggesting unique pathophysiological mechanisms. This study reports on multiple atherosclerotic plaques detected at autopsy in various vascular sites of a single subject, emphasizing their histological diversity and underscoring the systemic nature of atherosclerosis.
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Faa G, Cau R, Ravarino A, et al. Lessons from autopsy: Topographical variability of atherosclerosis plaques. Journal of Public Health Research. 2024;13(2). doi:10.1177/22799036241249659
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SAGE Publications
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Journal of Public Health Research, Vol. 13, Iss. 2
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Attribution-NonCommercial CC BY-NC