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The Use of Tissue Engineering to Fabricate Perfusable 3D Brain Microvessels in vitro
Udeni Galpayage Dona, Kalpani N. Hale, Jonathan Franklin Salako, Tobi Anandanatarajan, Akanksha Tran, Kiet A. De Ore, Brandon J. Galie, Peter Adam Ramirez, Servio Heybert Andrews, Allison Michelle
Udeni Galpayage Dona, Kalpani N.
Hale, Jonathan Franklin
Salako, Tobi
Anandanatarajan, Akanksha
Tran, Kiet A.
De Ore, Brandon J.
Galie, Peter Adam
Ramirez, Servio Heybert
Andrews, Allison Michelle
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Journal article
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2021-08-31
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Pathology and Laboratory Medicine
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https://doi.org/10.3389/fphys.2021.715431
Abstract
Tissue engineering of the blood-brain barrier (BBB) in vitro has been rapidly expanding to address the challenges of mimicking the native structure and function of the BBB. Most of these models utilize 2D conventional microfluidic techniques. However, 3D microvascular models offer the potential to more closely recapitulate the cytoarchitecture and multicellular arrangement of in vivo microvasculature, and also can recreate branching and network topologies of the vascular bed. In this perspective, we discuss current 3D brain microvessel modeling techniques including templating, printing, and self-assembling capillary networks. Furthermore, we address the use of biological matrices and fluid dynamics. Finally, key challenges are identified along with future directions that will improve development of next generation of brain microvasculature models.
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Galpayage Dona KNU, Hale JF, Salako T, Anandanatarajan A, Tran KA, DeOre BJ, Galie PA, Ramirez SH and Andrews AM (2021) The Use of Tissue Engineering to Fabricate Perfusable 3D Brain Microvessels in vitro. Front. Physiol. 12:715431. doi: 10.3389/fphys.2021.715431
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Frontiers in Physiology, Vol. 12
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