Item

The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus

Langedijk, Annefleur C.
; 
Vrancken, Bram
; 
Lebbink, Robert Jan
; 
Wilkins, Deidre
; 
Kelly, Elizabeth J.
; 
Baraldi, Eugenio
; 
MascareƱas de Los Santos, Abiel Homero
; 
Danilenko, Daria M.
; 
Choi, Eun Hwa
; 
Palomino, Marƭa AngƩlica
... show 10 more
Citations
Altmetric:
Genre
Journal article
Date
2024-04-10
Advisor
Committee member
Group
INFORM-RSV Study Group
Institute for Genomics and Evolutionary Medicine (iGEM) (Temple University)
Department
Biology
Subject
Phylogenetics
 Viral infection
 Molecular evolution
Permanent link to this record
https://scholarshare.temple.edu/handle/20.500.12613/11982
Collections
Faculty/Researcher Works
Show all metadata
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.1038/s41467-024-47118-6
Abstract
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.
Description
Citation
Langedijk, A.C., Vrancken, B., Lebbink, R.J. et al. The genomic evolutionary dynamics and global circulation patterns of respiratory syncytial virus. Nat Commun 15, 3083 (2024). https://doi.org/10.1038/s41467-024-47118-6
Citation to related work
Springer Science and Business Media
Has part
Nature Communications, Vol. 15, Iss. 1
ADA compliance
Embedded videos
License
Attribution CC BY
cb