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The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns
Akbarzadeh, Mahdi Riahi, Parisa Hossein Saeidian, Amir Zarkesh, Maryam Masjoudi, Sajedeh Asgarian, Sara Guity, Kamran Moheimani, Hamed Masoudi, Homayoon Amiri Roudbar, Mahmoud
Akbarzadeh, Mahdi
Riahi, Parisa
Hossein Saeidian, Amir
Zarkesh, Maryam
Masjoudi, Sajedeh
Asgarian, Sara
Guity, Kamran
Moheimani, Hamed
Masoudi, Homayoon
Amiri Roudbar, Mahmoud
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2024-02-27
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https://doi.org/10.1038/s41598-024-53504-3
Abstract
Dyslipidemia, as a metabolic risk factor, with the strongest and most heritable independent cause of cardiovascular diseases worldwide. We investigated the familial transmission patterns of dyslipidemia through a longitudinal family-based cohort, the Tehran Cardiometabolic Genetic Study (TCGS) in Iran. We enrolled 18,729 individuals (45% were males) aged > 18 years (mean: 38.15 (15.82)) and observed them over five 3-year follow-up periods. We evaluated the serum concentrations of total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol with the first measurement among longitudinal measures and the average measurements (AM) of the five periods. Heritability analysis was conducted using a mixed-effect framework with likelihood-based and Bayesian approaches. The periodic prevalence and heritability of dyslipidemia were estimated to be 65.7 and 42%, respectively. The likelihood of an individual having at least one dyslipidemic parent reveals an OR = 6.94 (CI 5.28–9.30) compared to those who do not have dyslipidemic parents. The most considerable intraclass correlation of family members was for the same-sex siblings, with ICC ~ 25.5%. For serum concentrations, heritability ranged from 33.64 to 60.95%. Taken together, these findings demonstrate that familial transmission of dyslipidemia in the Tehran population is strong, especially within the same-gender siblings. According to previous reports, the heritability of dyslipidemia in this population is considerably higher than the global average.
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Akbarzadeh, M., Riahi, P., Saeidian, A.H. et al. The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns. Sci Rep 14, 4739 (2024). https://doi.org/10.1038/s41598-024-53504-3
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Springer Science and Business Media
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Scientific Reports, Vol. 14, Iss. 1
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