Loading...
Regulation of miR-184 gene expression in early Drosophila development
Huang, Chen
Huang, Chen
Citations
Altmetric:
Genre
Thesis/Dissertation
Date
2011
Advisor
Committee member
Group
Department
Biology
Subject
Permanent link to this record
Collections
Files
Research Projects
Organizational Units
Journal Issue
DOI
http://dx.doi.org/10.34944/dspace/1457
Abstract
In Drosophila melanogaster, the transcription factor Dorsal initiates dorsal-ventral (DV) patterning in the early embryo by activating or repressing genes, such as the transcription factors Twist and Snail, along the DV axis. Previous studies have shown that the microRNA gene miR-184 in the ventral portion of the embryos (the prospective mesoderm) at the early stages of Drosophila embryogenesis. In order to identify the tissue-specific enhancer that regulates miR-184 expression in the mesoderm, we generated transgenic fly lines and observed the expression of a reporter gene under the control of a potential cis-regulatory module (CRM). Our results show that this CRM is responsible for the regulation of miR-184 and furthermore, it is activated by Twist.
Description
Citation
Citation to related work
Has part
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
Embedded videos
License
IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.