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Edgeworthia gardneri (Wall.) Meisn. Ethanolic Extract Attenuates Endothelial Activation and Alleviates Cardiac Ischemia-Reperfusion Injury
Lang, Xiaoya Zhong, Chao Su, Lingqing Qin, Manman Xie, Yanfei Shan, Dan Cui, Yaru Shi, Min Li, Min Quan, Hexiu
Lang, Xiaoya
Zhong, Chao
Su, Lingqing
Qin, Manman
Xie, Yanfei
Shan, Dan
Cui, Yaru
Shi, Min
Li, Min
Quan, Hexiu
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Journal article
Date
2024-02-29
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Cardiovascular Sciences
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https://doi.org/10.3390/molecules29051068
Abstract
Endothelial pro-inflammatory activation is pivotal in cardiac ischemia–reperfusion (I/R) injury pathophysiology. The dried flower bud of Edgeworthia gardneri (Wall.) Meisn. (EG) is a commonly utilized traditional Tibetan medicine. However, its role in regulating endothelium activation and cardiac I/R injury has not been investigated. Herein, we showed that the administration of EG ethanolic extract exhibited a potent therapeutic efficacy in ameliorating cardiac endothelial inflammation (p < 0.05) and thereby protecting against myocardial I/R injury in rats (p < 0.001). In line with the in vivo findings, the EG extract suppressed endothelial pro-inflammatory activation in vitro by downregulating the expression of pro-inflammatory mediators (p < 0.05) and diminishing monocytes’ firm adhesion to endothelial cells (ECs) (p < 0.01). Mechanistically, we showed that EG extract inhibited the nuclear factor kappa-B (NF-κB), c-Jun N-terminal kinase (JNK), extracellular regulated protein kinase (ERK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways to attenuate EC-mediated inflammation (p < 0.05). Collectively, for the first time, this study demonstrated the therapeutic potential of EG ethanolic extract in alleviating I/R-induced inflammation and the resulting cardiac injury through its inhibitory role in regulating endothelium activation.
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Lang, X.; Zhong, C.; Su, L.; Qin, M.; Xie, Y.; Shan, D.; Cui, Y.; Shi, M.; Li, M.; Quan, H.; et al. Edgeworthia gardneri (Wall.) Meisn. Ethanolic Extract Attenuates Endothelial Activation and Alleviates Cardiac Ischemia-Reperfusion Injury. Molecules 2024, 29, 1068. https://doi.org/10.3390/molecules29051068
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Molecules, Vol. 29, Iss. 5
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