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Insertional mutagenesis strategies in zebrafish

Sivasubbu, S
; 
Balciunas, D
; 
Amsterdam, A
; 
Ekker, SC
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Genre
Review
Journal
Date
2007-10-31
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Department
Subject
Animals
 DNA Transposable Elements
 Embryonic Stem Cells
 Mutagenesis, Insertional
 Retroviridae
 Zebrafish
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http://hdl.handle.net/20.500.12613/5616
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Insertional mutagenesis strategies in zebrafish.pdf
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DOI
10.1186/gb-2007-8-s1-s9
Abstract
We review here some recent developments in the field of insertional mutagenesis in zebrafish. We highlight the advantages and limitations of the rich body of retroviral methodologies, and we focus on the mechanisms and concepts of new transposon-based mutagenesis approaches under development, including prospects for conditional 'gene trapping' and 'gene breaking' approaches. © 2007 BioMed Central Ltd.
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Springer Science and Business Media LLC
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Genome Biology
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