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Multimodality therapy and innovative surgical techniques for successful resection and reconstruction of a rare and aggressive pleomorphic liposarcoma

Russo, Manual A. Garcia
; 
Sadeghi, John K.
; 
vonMehren, Margaret
; 
Friedberg, Joseph
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Journal article
Date
2024-03-27
Advisor
Committee member
Group
Fox Chase Cancer Center (Temple University)
Temple University. Hospital
Department
Thoracic Medicine and Surgery
Subject
Liposarcomas
 Pleural lavage
 Gore-Tex reconstruction
 Rare malignancy
 Penumonectomy
 Pleurectomy
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https://scholarshare.temple.edu/handle/20.500.12613/11681
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RussoEtAl-JournalArticle-2024-03.pdf
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https://doi.org/10.1016/j.sycrs.2024.100017
Abstract
Managing rare thoracic liposarcomas, accounting for < 1% of soft tissue sarcomas, demands tailored strategies. We explore effective approaches, considering tumor attributes and innovative techniques, and compare NCCNguided therapies and surgeries. Using PubMed, Embase, and Cochrane Library, we identified studies on thoracic liposarcomas. Data synthesis summarized findings, acknowledging rarity’s evidence limitations. This study reports a successful resection of a rare thoracic soft tissue sarcoma. Overcoming challenges through innovative techniques like hyperthermic pleural lavage and Gore-Tex® reconstruction, it underscores neoadjuvant therapies and surgical precision. Thoracic liposarcoma management demands tailored multidisciplinary approaches. Neoadjuvant chemotherapy, surgery, and adjuvant therapies are fundamental. Surgical ingenuity, like extrapleural pneumonectomy and novel reconstructions, ensures thorough tumor removal with minimal complications. Hyperthermic pleural lavage and Gore-Tex® offer promising refinements. Successful outcomes highlight potential for improved prognoses. Further research will optimize strategies for this rare, aggressive cancer.
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Manuel A. Garcia Russo, John K. Sadeghi, Margaret vonMehren, Joseph Friedberg, Multimodality therapy and innovative surgical techniques for successful resection and reconstruction of a rare and aggressive pleomorphic liposarcoma, Surgery Case Reports, Volume 2, 2024, 100017, ISSN 2950-1032, https://doi.org/10.1016/j.sycrs.2024.100017.
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Elsevier
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Surgery Case Reports, Vol. 2
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