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Association between fine particulate matter and fecundability in Henan, China: A prospective cohort study
Zhang, Rong Zhao, Jun Zhang, Yue Hong, Xiang Zhang, Hongguang Zheng, Hanyue Wu, Jingwei Wang, Yuanyua Peng, Zuoqi Zhang, Ya
Zhang, Rong
Zhao, Jun
Zhang, Yue
Hong, Xiang
Zhang, Hongguang
Zheng, Hanyue
Wu, Jingwei
Wang, Yuanyua
Peng, Zuoqi
Zhang, Ya
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Journal article
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2024-05-21
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Epidemiology and Biostatistics
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https://doi.org/10.1016/j.envint.2024.108754
Abstract
Objective: To investigate the relationship between ambient fine particulate matter (PM2.5) exposure and fecundability.
Methods: This study included 751,270 female residents from Henan Province who participated in the National Free Pre-conception Check-up Projects during 2015–2017. Ambient cycle-specific PM2.5 exposure was assessed at the county level for each participant using satellite-based PM2.5 concentration data at 1-km resolution. Cox proportional hazards models with time-varying exposure were used to estimate the association between fecundability and PM2.5 exposure, adjusted for potential individual risk factors.
Results: During the study period, 568,713 participants were pregnant, monthly mean PM2.5 concentrations varied from 25.5 to 114.0 µg/m3 across study areas. For each 10 µg/m3 increase in cycle-specific PM2.5, the hazard ratio for fecundability was 0.951 (95 % confidence interval: 0.950–0.953). The association was more pronounced in women who were older, with urban household registration, history of pregnancy, higher body mass index (BMI), hypertension, without exposure to tobacco, or whose male partners were older, with higher BMI, or hypertension.
Conclusion: In this population-based prospective cohort, ambient cycle-specific PM2.5 exposure was associated with reduced fecundability. These findings may support the adverse implications of severe air pollution on reproductive health.
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Rong Zhang, Jun Zhao, Yue Zhang, Xiang Hong, Hongguang Zhang, Hanyue Zheng, Jingwei Wu, Yuanyuan Wang, Zuoqi Peng, Ya Zhang, Lifang Jiang, Yueshu Zhao, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Bei Wang, Xu Ma, Association between fine particulate matter and fecundability in Henan, China: A prospective cohort study, Environment International, Volume 188, 2024, 108754, ISSN 0160-4120, https://doi.org/10.1016/j.envint.2024.108754.
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Elsevier
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Environment International, Vol. 188
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