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Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals
Qin, Manman Qian, Yuqing Huang, Lu Zhong, Chao Li, Mingdong Chen, Huanwen
Qin, Manman
Qian, Yuqing
Huang, Lu
Zhong, Chao
Li, Mingdong
Chen, Huanwen
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Journal article
Date
2023-01-13
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Committee member
Department
Cardiovascular Sciences
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https://doi.org/10.3389/fphar.2023.1110900
Abstract
Extraction electrospray ionization mass spectrometry (EESI-MS), due to the unique configuration of its ionization module, enables the effective ionization of trace molecules of interest in samples containing complex matrices with high sensitivity, high selectivity and high responding speed without requiring sample pretreatment, and allows high-energy molecular species to undergo specially designed reactions for advanced functionalization. The typical effects of operating conditions on the analytical performance of extraction electrospray ionization mass spectrometry for various pharmaceutical compounds, pharmaceutical preparations and herbal materials were systematically reviewed. The application prospect of extraction electrospray ionization in molecular functionalization for advanced drug discovery is also briefly introduced.
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Citation
Qin M, Qian Y, Huang L, Zhong C, Li M, Yu J and Chen H (2023) Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals. Front. Pharmacol. 14:1110900. doi: 10.3389/fphar.2023.1110900
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Frontiers Media
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Frontiers in Pharmacology, Vol. 14
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