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Efficacy evaluation of a bivalent subunit vaccine against classical swine fever virus and porcine circovirus type 2
Chen, Yu-San Lee, Chang-Ye Wu, Chi-Chien Kao, Pei-Lun Chen, Tai-An Huang, Yahui Chung, Wen-Bin Kuo, Tsun-Yung Chen, Charles
Chen, Yu-San
Lee, Chang-Ye
Wu, Chi-Chien
Kao, Pei-Lun
Chen, Tai-An
Huang, Yahui
Chung, Wen-Bin
Kuo, Tsun-Yung
Chen, Charles
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Journal article
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2024-02-06
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Biology
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https://doi.org/10.1038/s41598-024-53624-w
Abstract
Classical swine fever virus (CSFV) and porcine circovirus type 2 (PCV2) are two of the most devastating and economically significant pathogens affecting pig populations worldwide. Administration of a combination of vaccines against swine pathogens has been demonstrated to be as efficacious as the administration of single vaccines. In this study, we developed and tested a novel bivalent subunit vaccine against CSFV and PCV2. The safety and efficacy of this vaccine were demonstrated in mice and specific pathogen-free (SPF) piglets. In addition to investigating the serological responses after immunization, challenge studies with both viruses were also conducted. The results showed that this CSFV/PCV2 bivalent vaccine elicited a high level of neutralizing antibodies against both viruses and provided protection in challenge studies. In conclusion, the CSFV/PCV2 bivalent vaccine is safe and effective against CSFV or PCV2 challenge.
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Chen, YS., Lee, CY., Wu, CC. et al. Efficacy evaluation of a bivalent subunit vaccine against classical swine fever virus and porcine circovirus type 2. Sci Rep 14, 2997 (2024). https://doi.org/10.1038/s41598-024-53624-w
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Springer Science and Business Media
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Scientific Reports, Vol. 14, Iss. 1
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