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Characterization of Metabolic Phenotypes in Acute Myeloid Leukemia
Wilkinson, Anya S.
Wilkinson, Anya S.
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Research project
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2026-04-09
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Biology
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Wilkinson-ResearchProject-2026.pdf
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https://doi.org/10.34944/psrr-7105
Abstract
The mitochondria is an essential cellular organelle that regulates metabolism and produces ATP for the cell, primarily by the electron transport chain (ETC). Recently, our lab proposed a novel metabolon of Complex II (C-II) of the ETC as regulated by MICU2, a calcium-sensing protein part of the mitochondrial calcium uniporter complex (mtCU). Also, it has recently been shown that acute myeloid leukemia (AML) cell lines are sensitive to C-II inhibition. Therefore, we hypothesize that knocking down MICU2 in AML cells will reduce C-II activity, increase cell death, and alter metabolism. Our preliminary results shown here indicate that knocking down MICU2 (MICU2KD) in AML cells decreases viability and C-II activity. These preliminary conclusions support that a MICU2/C-II interaction is required to maintain cellular metabolism, and that MICU2 can function independent of calcium and the mtCU. Investigating the metabolic character of AML cells improves our understanding of a metabolic weak point in an aggressive cancer, potentially leading to novel therapeutic research.
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