Loading...
Exploring the Implications of New-Onset Diabetes in COVID-19: A Narrative Review
Pergolizzi, Joseph LeQuang, Jo Ann K. Breve, Frank Magnusson, Peter M. Varrassi, Giustino
Pergolizzi, Joseph
LeQuang, Jo Ann K.
Breve, Frank
Magnusson, Peter M.
Varrassi, Giustino
Citations
Altmetric:
Genre
Journal article
Date
2023-01-03
Advisor
Committee member
Group
Department
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.7759/cureus.33319
Abstract
Post-viral new-onset diabetes has been an important feature of the COVID-19 pandemic. It is not always clear if new-onset diabetes is the unmasking of a previously undiagnosed condition, the acceleration of prediabetes, or new-onset diabetes that would not have otherwise occurred. Even asymptomatic cases of COVID-19 have been associated with new-onset diabetes. Diabetes that emerges during acute COVID-19 infection tends to have an atypical presentation, characterized by hyperglycemia and potentially life-threatening diabetic ketoacidosis. It is not always clear if new-onset diabetes is type 1 or type 2 diabetes mellitus. Many cases of COVID-associated diabetes appear to be type 1 diabetes, which is actually an autoimmune disorder. The clinical course varies temporally and with respect to outcomes; in some cases, diabetes resolves completely or improves incrementally after recovery from COVID-19. Disruptions in macrophagy caused by COVID-19 infection along with an exaggerated inflammatory response that can occur in COVID-19 also play a role. Those who survive COVID-19 remain at a 40% elevated risk for diabetes in the first year, even if their case of COVID-19 was not particularly severe. A subsequent post-pandemic wave of new diabetes patients may be expected.
Description
Citation
Pergolizzi J, LeQuang J K, Breve F, et al. (January 03, 2023) Exploring the Implications of New-Onset Diabetes in COVID-19: A Narrative Review. Cureus 15(1): e33319. doi:10.7759/cureus.33319
Citation to related work
Springer
Has part
Cureus: Journal of Medical Science, Vol. 15, Iss. 1
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu