Loading...
Synthesis and properties of lysosome-specific photoactivatable probes for live-cell imaging
Tran, MN Rarig, RAF Chenoweth, DM
Tran, MN
Rarig, RAF
Chenoweth, DM
Citations
Altmetric:
Genre
Journal Article
Date
2015-08-01
Advisor
Committee member
Group
Department
Subject
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
10.1039/c5sc01601k
Abstract
© The Royal Society of Chemistry. Fluorescent dyes have become increasingly important in cell biology since they enable high signal-to-noise and selectivity in visualizing subcellular organelles. Photoactivatable dyes allow for tracking and monitoring of a subset of cells or organelles. Here, we report the synthesis and application of a new class of large Stokes shift fluorescent dyes that are water-soluble, cell permeable, non-cytotoxic, and lysosome-specific. Additionally, we demonstrate temporally controlled sequential photoactivation of individual cells in close spatial proximity.
Description
Citation
Citation to related work
Royal Society of Chemistry (RSC)
Has part
Chemical Science
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu