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The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses
Quinteros, Susel Loli Snyder, Nathaniel W. Chatoff, Adam Ryan, Fiona O'Brien, Bronwyn Donnelly, Sheila
Quinteros, Susel Loli
Snyder, Nathaniel W.
Chatoff, Adam
Ryan, Fiona
O'Brien, Bronwyn
Donnelly, Sheila
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Journal article
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2024-04-05
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Cardiovascular Sciences
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https://doi.org/10.1002/eji.202350643
Abstract
We implicate a phenotype of trained immunity in bone-marrow-derived macrophages in the onset and progression of type 1 diabetes in nonobese diabetic mice. Treatment with FhHDM-1 reversed immune training, reducing histone methylation and glycolysis, and decreasing proinflammatory cytokine production to the same level as macrophages from nondiabetic immune-competent BALB/c mice.
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Quinteros, S.L., Snyder, N.W., Chatoff, A., Ryan, F., O'Brien, B. and Donnelly, S. (2024), The helminth-derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone-marrow-derived macrophages and regulates proinflammatory responses. Eur. J. Immunol., 54: 2350643. https://doi.org/10.1002/eji.202350643
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Wiley
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European Journal of Immunology, Vol. 54, Iss. 6
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