Thumbnail Image
Item

Alveolar Organoids in Lung Disease Modeling

Purev, Enkhee
; 
Bahmed, Karim
; 
Kosmider, Beata
Citations
Altmetric:
Genre
Journal article
Date
2024-01-16
Advisor
Committee member
Group
Center for Inflammation and Lung Research (Temple University)
Department
Microbiology, Immunology, and Inflammation
Thoracic Medicine and Surgery
Cardiovascular Sciences
Subject
AT2 cells
 Alveolar organoids
 Diseases
 Lung
 Regeneration
Permanent link to this record
https://scholarshare.temple.edu/handle/20.500.12613/11737
Collections
Faculty/Researcher Works
Show all metadata
Files
Thumbnail Image
PurevEtAl-JournalArticle-2024-01.pdf
Adobe PDF, 1.47 MB
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.3390/biom14010115
Abstract
Lung organoids display a tissue-specific functional phenomenon and mimic the features of the original organ. They can reflect the properties of the cells, such as morphology, polarity, proliferation rate, gene expression, and genomic profile. Alveolar type 2 (AT2) cells have a stem cell potential in the adult lung. They produce and secrete pulmonary surfactant and proliferate to restore the epithelium after damage. Therefore, AT2 cells are used to generate alveolar organoids and can recapitulate distal lung structures. Also, AT2 cells in human-induced pluripotent stem cell (iPSC)- derived alveolospheres express surfactant proteins and other factors, indicating their application as suitable models for studying cell–cell interactions. Recently, they have been utilized to define mechanisms of disease development, such as COVID-19, lung cancer, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease. In this review, we show lung organoid applications in various pulmonary diseases, drug screening, and personalized medicine. In addition, stem cell-based therapeutics and approaches relevant to lung repair were highlighted. We also described the signaling pathways and epigenetic regulation of lung regeneration. It is critical to identify novel regulators of alveolar organoid generations to promote lung repair in pulmonary diseases.
Description
Citation
Purev, E.; Bahmed, K.; Kosmider, B. Alveolar Organoids in Lung Disease Modeling. Biomolecules 2024, 14, 115. https://doi.org/10.3390/biom14010115
Citation to related work
MDPI
Has part
Biomolecules, Vol. 14, Iss. 1
ADA compliance
Embedded videos
License
Attribution CC BY
cb