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Unrecognized opportunities: The landscape of pediatric kidney-paired donation in the United States

Verbesey, Jennifer
; 
Thomas, Alvin G.
; 
Waterman, Amy D.
; 
Karhadkar, Sunil
; 
Cassell, Victoria R.
; 
Segev, Dorry L.
; 
Hogan, Julien
; 
Cooper, Matt
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Journal article
Date
2024-01-19
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Temple University. Hospital
Department
Surgery
Subject
Donor exchange
 Living donation
 Paired donation
 Pediatric
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https://scholarshare.temple.edu/handle/20.500.12613/11712
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Karhadkar-JournalArticle-2024-01.pdf
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DOI
https://doi.org/10.1111/petr.14657
Abstract
Background Pediatric (age < 18 years) kidney transplant (KT) candidates face increasingly complex choices. The 2014 kidney allocation system nearly doubled wait times for pediatric recipients. Given longer wait times and new ways to optimize compatibility, more pediatric candidates may consider kidney-paired donation (KPD). Motivated by this shift and the potential impact of innovations in KPD practice, we studied pediatric KPD procedures in the US from 2008 to 2021. Methods We describe the characteristics and outcomes of pediatric KPD recipients with comparison to pediatric non-KPD living donor kidney transplants (LDKT), pediatric LDKT recipients, and pediatric deceased donor (DDKT) recipients. Results Our study cohort includes 4987 pediatric DDKTs, 3447 pediatric non-KPD LDKTs, and 258 pediatric KPD transplants. Fewer centers conducted at least one pediatric KPD procedure compared to those that conducted at least one pediatric LDKT or DDKT procedure (67, 136, and 155 centers, respectively). Five centers performed 31% of the pediatric KPD transplants. After adjustment, there were no differences in graft failure or mortality comparing KPD recipients to non-KPD LDKT, LDKT, or DDKT recipients. Discussion We did not observe differences in transplant outcomes comparing pediatric KPD recipients to controls. Considering these results, KPD may be underutilized for pediatric recipients. Pediatric KT centers should consider including KPD in KT candidate education. Further research will be necessary to develop tools that could aid clinicians and families considering the time horizon for future KT procedures, candidate disease and histocompatibility characteristics, and other factors including logistics and donor protections.
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Citation
Verbesey J, Thomas AG, Waterman AD, et al. Unrecognized opportunities: The landscape of pediatric kidney-paired donation in the United States. Pediatric Transplantation. 2023; 00:e14657. doi:10.1111/petr.14657
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Wiley
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Pediatric Transplantation, Vol. 28, Iss. 1
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