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Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report
Jung, Regina Ly, Kevin Taniguchi, Michiko Arriola, Aileen Grace Gravante, Christopher Shinn, Derek Mathew, Leena Hamad, Eman Geier, Steven Liacini, Abdelhamid
Jung, Regina
Ly, Kevin
Taniguchi, Michiko
Arriola, Aileen Grace
Gravante, Christopher
Shinn, Derek
Mathew, Leena
Hamad, Eman
Geier, Steven
Liacini, Abdelhamid
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Journal article
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2024-02-12
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Pathology and Laboratory Medicine
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https://doi.org/10.3390/ijms25042218
Abstract
HLA donor-specific antibodies (DSAs) pre and post transplant increase the risk of antibody-mediated rejection (AMR) and lead to poor graft survival. Increasing data exist to support the involvement of non-HLA antibodies in triggering an immunological response. The development of non-HLA antibodies specific for AT1R is associated with poor clinical outcomes in orthotopic heart transplant recipients. This case presents an investigation of non-HLA antibodies in a 56-year-old female heart transplant recipient diagnosed with AMR in the absence of DSAs.
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Jung, R.; Ly, K.; Taniguchi, M.; Arriola, A.G.; Gravante, C.; Shinn, D.; Mathew, L.; Hamad, E.; Geier, S.; Liacini, A. Improved Graft Function following Desensitization of Anti-AT1R and Autoantibodies in a Heart Transplant Recipient Negative for Donor-Specific Antibodies with Antibody-Mediated Rejection: A Case Report. Int. J. Mol. Sci. 2024, 25, 2218. https://doi.org/10.3390/ijms25042218
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International Journal of Molecular Sciences, Vol. 25, Iss. 4
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