Loading...
Burden of AML, 1990-2019: Estimates From the Global Burden of Disease Study
Jani, Chinmay T. Ahmed, Alaaeldin Singh, Harpreet Mouchati, Christian Al Omari, Omar Bhatt, Padmanabh S. Sharma, Rajesh Farooq, Minaam Liu, Weitao Shalhoub, Joseph
Jani, Chinmay T.
Ahmed, Alaaeldin
Singh, Harpreet
Mouchati, Christian
Al Omari, Omar
Bhatt, Padmanabh S.
Sharma, Rajesh
Farooq, Minaam
Liu, Weitao
Shalhoub, Joseph
Citations
Altmetric:
Genre
Journal article
Date
2023-11-22
Advisor
Committee member
Group
Department
Subject
Permanent link to this record
Collections
Research Projects
Organizational Units
Journal Issue
DOI
https://doi.org/10.1200/go.23.00229
Abstract
Purpose: AML accounts for 80% of acute leukemia in adults. While progress has been made in treating younger patients in the past 2 decades, there has been limited improvement for older patients until recently. This study examines the global and European Union (EU) 15+ trends in AML between 1990 and 2019. Methods: We extracted age-standardized incidence rates (ASIRs), age-standardized death rates (ASMRs), and disability-adjusted life years, stratified by sex from the Global Burden of Disease Study database, and mortality-to-incidence ratio (MIR) were computed. Trends were compared using Joinpoint regression. Results: The findings show a global increase in AML incidence for both sexes from 1990 to 2019. In the EU15+ countries, most countries exhibited an increase in ASIR for both sexes. Joinpoint revealed that globally for male patients, ASIR steadily increased until 2010, remained stable until 2015 followed by a decline till 2019. Similar trends were observed in female patients. For ASMR, although there was an increase globally and in most EU15+ countries, there was a statistically significant decrease in mortality rates globally and in the majority of EU15+ countries in recent years. MIR improved in both sexes globally. On age stratification, AML burden was highest among older groups (55 years and older), while the lowest rates were observed in younger than 20 years.
Conclusion: The findings from our study indicate a global rise in AML incidence and mortality in both sexes and decrease in MIR from 1990 to 2019 suggesting a better survival. However, on Joinpoint analysis, there is no change in MIR in women in the past decade and past 4 years in men indicating plateau in survival trends despite recent advances.
Description
Citation
Chinmay T. Jani et al., Burden of AML, 1990-2019: Estimates From the Global Burden of Disease Study. JCO Glob Oncol 9, e2300229(2023). DOI:10.1200/GO.23.00229
Citation to related work
American Society of Clinical Oncology
Has part
JCO Global Oncology, Vol. 9
ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu