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Behavioral evidence of impaired self-referential processing in patients with affective disorders and first-episode schizophrenia
Zhao, Yanli Xu, Jiahua Hong, Jiangyue Xu, Xuejing Fan, Hongzhen Zhang, Jinguo Li, Dong Chen, Jingxu Wu, Yaxue Li, Yanli
Zhao, Yanli
Xu, Jiahua
Hong, Jiangyue
Xu, Xuejing
Fan, Hongzhen
Zhang, Jinguo
Li, Dong
Chen, Jingxu
Wu, Yaxue
Li, Yanli
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Journal article
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2024-05-10
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Media and Communication
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https://doi.org/10.1038/s41598-024-60498-5
Abstract
Despite the critical role of self-disturbance in psychiatric diagnosis and treatment, its diverse behavioral manifestations remain poorly understood. This investigation aimed to elucidate unique patterns of self-referential processing in affective disorders and first-episode schizophrenia. A total of 156 participants (41 first-episode schizophrenia [SZ], 33 bipolar disorder [BD], 44 major depressive disorder [MDD], and 38 healthy controls [HC]) engaged in a self-referential effect (SRE) task, assessing trait adjectives for self-descriptiveness, applicability to mother, or others, followed by an unexpected recognition test. All groups displayed preferential self- and mother-referential processing with no significant differences in recognition scores. However, MDD patients showed significantly enhanced self-referential recognition scores and increased bias compared to HC, first-episode SZ, and BD. The present study provides empirical evidence for increased self-focus in MDD and demonstrates that first-episode SZ and BD patients maintain intact self-referential processing abilities. These findings refine our understanding of self-referential processing impairments across psychiatric conditions, suggesting that it could serve as a supplementary measure for assessing treatment response in first-episode SZ and potentially function as a discriminative diagnostic criterion between MDD and BD.
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Zhao, Y., Xu, J., Hong, J. et al. Behavioral evidence of impaired self-referential processing in patients with affective disorders and first-episode schizophrenia. Sci Rep 14, 10754 (2024). https://doi.org/10.1038/s41598-024-60498-5
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Springer Science and Business Media
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Scientific Reports, Vol. 14, Iss. 1
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