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Comparing Intracanalicular and Topical Steroid Use in Patients Undergoing Pterygium Surgery

Rhee, Michelle K.
; 
Zakher, Meena
; 
Najac, Michael
; 
Arias, Harold
; 
Jo, Jace
; 
Gorham, Richard
; 
Moadel, Ken
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Journal article
Date
2024-04
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Intracanalicular steroid
 Pterygium
 Drug delivery
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https://scholarshare.temple.edu/handle/20.500.12613/11973
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DOI
https://doi.org/10.1097/icl.0000000000001075
Abstract
Objective: The study received funding from Ocular Therapeutix, Inc., Bedford, MA. We undertook this study to compare the efficacy of intracanalicular dexamethasone 0.4 mg with topical prednisolone acetate (PA) 1% in controlling postoperative pain and inflammation in patients undergoing pterygium surgery. Methods: This was an open-label, prospective, interventional, nonrandomized comparative trial. Thirty patients were assigned to one of the following groups: Group A [intracanalicular insert of 0.4 mg dexamethasone placed into upper and lower puncta during the procedure, followed by at postoperative month 1 visit institution of topical PA 1% twice daily × 2 weeks then once daily × 2 weeks] or Group B [nonintervention group with institution on postoperative day 1 topical PA 1% every 2 hours × 2 weeks then four times per day × 2 weeks then twice daily × 2 weeks then once daily × 2 weeks]. Results: Fifteen cases and 15 controls were enrolled. There was no statistical difference in patient-reported pain or satisfaction between the case and control groups at 1 day; 1 week; and 1, 3, and 6 months postoperatively. There was no significant difference in time to an ocular hyperemia score of 0 between the two groups. There was no difference in the rate of corneal reepithelialization and recurrence rate (two controls). Nine eyes had transient ocular hypertension (seven cases and two controls). Conclusion: Intracanalicular dexamethasone 0.4 mg may reduce the medication burden for patients who need prolonged postoperative steroid therapy as is routine in the setting of pterygium surgery. It is a safe and effective alternative to PA 1% drops alone for postoperative control of pain and inflammation in pterygium surgery.
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Rhee, Michelle K. M.D.; Zakher, Meena M.D.; Najac, Michael B.A.; Arias, Harold O.D.; Jo, Jace B.A.; Gorham, Richard M.S.; Moadel, Ken M.D.. Comparing Intracanalicular and Topical Steroid Use in Patients Undergoing Pterygium Surgery. Eye & Contact Lens: Science & Clinical Practice 50(4):p 183-188, April 2024. | DOI: 10.1097/ICL.0000000000001075
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Lippincott Williams and Wilkins
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Eye & Contact Lens, Vol. 50, Iss. 4
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