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    NICOTINE WITHDRAWAL AND DEFICITS IN COGNITIVE FLEXIBILITY: POSSIBLE TIES TO ABERRATIONS IN FRONTOSTRIATAL BDNF SIGNALING

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    Genre
    Thesis/Dissertation
    Date
    2017
    Author
    Cole, Robert David
    Advisor
    Parikh, Vinay
    Committee member
    Gould, Thomas John, 1966-
    Briand, Lisa A.
    Bangasser, Debra A.
    Chein, Jason M.
    Ellman, Lauren M.
    Department
    Psychology
    Subject
    Neurosciences
    Bdnf
    Cognitive Flexibility
    Dorsal Striatum
    Nicotine Withdrawal
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/990
    
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    DOI
    http://dx.doi.org/10.34944/dspace/972
    Abstract
    Nicotine addiction continues to be a leading cause of preventable death worldwide. Despite the plethora of available treatments for smoking cessation, smoking relapse after attempts to quit remains high. It is possible that impairments in cognitive flexibility and underlying neurochemical circuits in nicotine addicts may foster maladaptive behaviors that affect individuals’ ability to refrain from taking drugs. Here we characterized the effects of spontaneous nicotine withdrawal on cognitive flexibility in mice using an operant strategy set-shifting task. Because frontostriatal circuits are critical for cognitive flexibility and brain-derived neurotrophic factor (BDNF) modulates glutamate plasticity, we also explored the effects of nicotine withdrawal on these neurochemical substrates. Adult male C57BL/6J mice were trained in an operant task that required the animals to switch from using a spatial response-driven strategy to a visual cue-based strategy to achieve rewards. Mice were exp
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