Antifungal properties of (2S, 4R)-Ketoconazole sulfonamide analogs
dc.creator | Blass, Benjamin E. | |
dc.creator | Puri, Sumant | |
dc.creator | Sharma, Rishabh | |
dc.creator | Day, Brian M. | |
dc.date.accessioned | 2024-03-13T20:24:00Z | |
dc.date.available | 2024-03-13T20:24:00Z | |
dc.date.issued | 2022-08-29 | |
dc.identifier.citation | Blass BE, Puri S, Sharma R and Day BM (2022) Antifungal properties of (2S, 4R)-Ketoconazole sulfonamide analogs. Front. Drug. Discov. 2:1000827. doi: 10.3389/fddsv.2022.1000827 | |
dc.identifier.issn | 2674-0338 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12613/9897 | |
dc.description.abstract | Invasive candidiasis remains a significant health concern, as it is associated with a high mortality risk. In addition, the risk of infection is significantly elevated in immunocompromised patients such as those with HIV, cancer, or those taking imcmunosuppressive drugs as a result of organ transplantation. The majority of these cases are caused by C. albicans, and C. glabrata is the second most common cause. These infections are typically treated using approved antifungal agents, but the rise of drug-resistant fungi is a serious concern. As part of our on-going effort to identify novel antifungal agents, we have studied the in vitro antifungal properties of a series of sulfonamide analogs of (2S, 4R)-Ketoconazole. Herein we report on the in vitro activity against the key fungal pathogens C. albicans, and C. glabrata. | |
dc.format.extent | 6 pages | |
dc.language | English | |
dc.language.iso | eng | |
dc.relation.ispartof | Faculty/ Researcher Works | |
dc.relation.haspart | Frontiers in Drug Discovery | |
dc.relation.isreferencedby | Frontiers Media | |
dc.rights | Attribution CC BY | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Antifungal agent | |
dc.subject | Antimicrobial agents | |
dc.subject | Ketoconazole | |
dc.subject | Candida albicans | |
dc.subject | Candida glabrata | |
dc.title | Antifungal properties of (2S, 4R)-Ketoconazole sulfonamide analogs | |
dc.type | Text | |
dc.type.genre | Journal article | |
dc.contributor.group | Oral Microbiome Research Laboratory (Temple University) | |
dc.description.department | Pharmaceutical Sciences | |
dc.relation.doi | http://dx.doi.org/10.3389/fddsv.2022.1000827 | |
dc.ada.note | For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu | |
dc.description.schoolcollege | Temple University. School of Pharmacy | |
dc.description.schoolcollege | Kornberg School of Dentistry | |
dc.creator.orcid | Puri|0000-0002-5509-007X | |
dc.temple.creator | Blass, Benjamin E. | |
dc.temple.creator | Puri, Sumant | |
dc.temple.creator | Sharma, Rishabh | |
dc.temple.creator | Day, Brian M. | |
refterms.dateFOA | 2024-03-13T20:24:00Z |