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dc.creatorZhou, Yilun
dc.creatorWang, Dongxue
dc.creatorLi, Hao
dc.creatorPan, Yuesong
dc.creatorXiang, Xianglong
dc.creatorWu, Yu
dc.creatorXie, Xuewei
dc.creatorWang, Xianwei
dc.creatorLuo, Yang
dc.creatorMeng, Xia
dc.creatorLin, Jinxi
dc.creatorWang, Hong
dc.creatorHuo, Yong
dc.creatorMatsushita, Kunihiro
dc.creatorChen, Jing
dc.creatorHou, Fan Fan
dc.creatorWang, Yongjun
dc.identifier.citationZhou, Y., Wang, D., Li, H. et al. Association of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry. BMC Nephrol 23, 188 (2022).
dc.description.abstractBackground: Acute kidney disease (AKD) evolves a spectrum of acute and subacute kidney disease requiring a global strategy to address. The present study aimed to explore the impact of AKD on the prognosis of ischemic stroke. Methods: The Third China National Stroke Registry (CNSR-III) was a nationwide registry of ischemic stroke or transient ischemic attack between August 2015 and March 2018. As a subgroup of CNSR-III, the patients who had serum creatinine (sCr) and serum cystatin C (sCysC) centrally tested on admission and at 3-month, and with 1-year follow-up data were enrolled. Modified AKD criteria were applied to identify patients with AKD during the first 3 months post stroke according to the guidelines developed by the Kidney Disease: Improving Global Outcomes in 2012. The primary clinical outcome was 1-year all-cause death, and secondary outcomes were stroke recurrence and post stroke disability. Results: Five thousand sixty-five patients were recruited in the study. AKD was identified in 3.9%, 6.7%, 9.9% and 6.2% of the patients by using sCr, sCr-based estimated glomerular filtration rate (eGFRsCr), sCysC-based eGFR (eGFRsCysC), and combined sCr and sCysC-based eGFR (eGFRsCr+sCysC) criteria, respectively. AKD defined as sCr or eGFRsCr criteria significantly increased the risk of all-cause mortality (adjusted HR 2.67, 95% CI: 1.27–5.61; adjusted HR 2.19, 95% CI: 1.17–4.10) and post stroke disability (adjusted OR 1.60, 95% CI: 1.04–2.44; adjusted OR 1.51, 95% CI: 1.08–2.11). AKD diagnosed by eGFRsCysC or eGFRsCr+sCysC criteria had no significant impact on the risk of all-cause death and post stroke disability. AKD, defined by whichever criteria, was not associated with the risk of stroke recurrence in the adjusted model. Conclusions: AKD, diagnosed by sCr or eGFRsCr criteria, were independently associated with 1-year all-cause death and post stroke disability in Chinese ischemic stroke patients.
dc.format.extent10 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartBMC Nephrology, Vol. 23
dc.rightsAttribution CC BY
dc.subjectAcute kidney disease
dc.titleAssociation of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry
dc.type.genreJournal article
dc.contributor.groupCenter for Metabolic Disease Research (Temple University)
dc.description.departmentMicrobiology, Immunology and Inflammation
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorWang, Xianwei
dc.temple.creatorWang, Hong

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