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dc.contributor.editorPapadia, Francesco Saverio
dc.creatorShikora, Scott A.
dc.creatorWolfe, Bruce M.
dc.creatorApovian, Caroline M.
dc.creatorAnvari, Mehran
dc.creatorSarwer, David
dc.creatorGibbons, Robert D.
dc.creatorIkramuddin, Sayeed
dc.creatorMiller, Christopher J.
dc.creatorKnudson, Mark B.
dc.creatorTweden, Katherine S.
dc.creatorSarr, Michael G.
dc.creatorBillington, Charles J.
dc.date.accessioned2020-04-22T19:14:12Z
dc.date.available2020-04-22T19:14:12Z
dc.date.issued2015-06-28
dc.identifier.citationScott A. Shikora, Bruce M. Wolfe, Caroline M. Apovian, et al., “Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial,” Journal of Obesity, vol. 2015, Article ID 365604, 8 pages, 2015. https://doi.org/10.1155/2015/365604
dc.identifier.issn2090-0708
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/81
dc.identifier.urihttp://hdl.handle.net/20.500.12613/94
dc.description.abstractBackground/Objectives. Vagal block therapy (vBloc) is effective for moderate to severe obesity at one year. Subjects/Methods. The ReCharge trial is a double-blind, randomized controlled clinical trial of 239 participants with body mass index (BMI) of 40 to 45 kg/m or 35 to 40 kg/m with one or more obesity-related conditions. Interventions were implantation of either vBloc or Sham devices and weight management counseling. Mixed models assessed percent excess weight loss (%EWL) and total weight loss (%TWL) in intent-to-treat analyses. At 18 months, 142 (88%) vBloc and 64 (83%) Sham patients remained enrolled in the study. Results. 18-month weight loss was 23% EWL (8.8% TWL) for vBloc and 10% EWL (3.8% TWL) for Sham (P < 0.0001). vBloc patients largely maintained 12-month weight loss of 26% EWL (9.7% TWL). Sham regained over 40% of the 17% EWL (6.4% TWL) by 18 months. Most weight regain preceded unblinding. Common adverse events of vBloc through 18 months were heartburn/dyspepsia and abdominal pain; 98% of events were reported as mild or moderate and 79% had resolved. Conclusions. Weight loss with vBloc was sustained through 18 months, while Sham regained weight between 12 and 18 months. vBloc is effective with a low rate of serious complications.
dc.format.extent9 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartJournal of Obesity, Vol. 2015, Article ID 365604
dc.relation.isreferencedbyHindawi
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleClinical Study: Sustained Weight Loss with Vagal Nerve Blockade but Not with Sham: 18-Month Results of the ReCharge Trial
dc.typeText
dc.type.genreJournal article
dc.description.departmentSocial and Behavioral Sciences
dc.relation.doihttps://doi.org/10.1155/2015/365604
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Public Health
dc.creator.orcid0000-0003-1033-5528
dc.temple.creatorSarwer, David B.
refterms.dateFOA2020-04-22T19:14:12Z


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