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dc.creatorRegier, P.S.
dc.creatorSinko, Laura
dc.creatorJagannathan, K.
dc.creatorAryal, S.
dc.creatorTeitelman, A.M.
dc.creatorChildress, A.R.
dc.identifier.citationRegier, P.S., Sinko, L., Jagannathan, K. et al. In young women, a link between childhood abuse and subliminal processing of aversive cues is moderated by impulsivity. BMC Psychiatry 22, 159 (2022).
dc.description.abstractBackground: Childhood maltreatment is a serious public health concern. The association between child maltreatment, adverse behaviors, mental health outcomes, and alterations to brain function and structure have begun to be characterized. Less is known about the specific associations of maltreatment subtypes with cue-response to evocative cues and the moderating effects of confounding mental health/behavioral variables. Methods: Fifty-four emerging adult women (aged 18–24) completed assessments for behaviors, mental health, and childhood maltreatment. They participated in a fMRI task featuring passive viewing of evocative (33 ms) cues presented by “backward masking” to prevent conscious processing. Correlations of abuse/neglect scores, behavioral/mental health factors, and brain function were assessed. Follow-up analyses investigated the moderating effects of behavioral/mental health factors on maltreatment and brain relationships. Results: Greater frequency of childhood abuse and neglect were correlated with higher scores of impulsivity, depressive symptoms, and anxious attachment. Childhood abuse was positively associated with increased medial orbitofrontal cortical (mOFC) response to aversive (vs. neutral) cues. Among the behavioral/mental health variables, only impulsivity appeared to have a moderating effect on the relationship between childhood abuse and brain response to aversive cues. Conclusions: The link between childhood abuse and a heightened mOFC response to “unseen” aversive stimuli, moderated by impulsivity, adds to the growing literature on the impact of prior adversity on brain function. These findings offer further understanding for the way in which childhood maltreatment affects the brain processing of negative stimuli, helping to explain the well-documented link between childhood maltreatment and a variety of adverse outcomes in adulthood.
dc.format.extent12 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartBMC Psychiatry, Vol. 22
dc.rightsAttribution CC BY
dc.subjectChildhood maltreatment
dc.subjectNegative cues
dc.subjectMental health
dc.titleIn young women, a link between childhood abuse and subliminal processing of aversive cues is moderated by impulsivity
dc.type.genreJournal article
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeTemple University. College of Public Health
dc.temple.creatorSinko, Laura

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