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dc.creatorThiruvengadam, Nikhil R.
dc.creatorForde, Kimberly A.
dc.creatorMiranda, Janille
dc.creatorKim, Christopher
dc.creatorBehr, Spencer
dc.creatorMasharani, Umesh
dc.creatorArain, Mustafa A.
dc.date.accessioned2023-12-21T19:37:02Z
dc.date.available2023-12-21T19:37:02Z
dc.date.issued2022-02-19
dc.identifier.citationThiruvengadam, Nikhil R. MD1,2,3,4; Forde, Kimberly A. MD, PhD5; Miranda, Janille BS4; Kim, Christopher MD6; Behr, Spencer MD6; Masharani, Umesh MBBS7; Arain, Mustafa A. MD4,8. Disconnected Pancreatic Duct Syndrome: Pancreatitis of the Disconnected Pancreas and Its Role in the Development of Diabetes Mellitus. Clinical and Translational Gastroenterology 13(2):p e00457, February 2022. | DOI: 10.14309/ctg.0000000000000457
dc.identifier.issn2155-384X
dc.identifier.urihttp://hdl.handle.net/20.500.12613/9379
dc.description.abstractINTRODUCTION: Disconnected pancreatic duct syndrome (DPDS) is a recognized complication of necrotizing pancreatitis (NP). Manifestations include recurrent peripancreatic fluid collections (R-PFC) and pancreatocutaneous fistulae (PC-Fistulae). Pancreatitis of the disconnected pancreatic segment (DPDS-P) and its relationship to new-onset diabetes after pancreatitis (NODAP) are not well characterized. METHODS: We performed a retrospective cohort study of consecutive patients with NP admitted to University of California, San Francisco from January 2011 to June 2019. A diagnosis of a disconnected pancreatic duct (PD) was confirmed using computed tomography and magnetic resonance cholangiopancreatography/endoscopic retrograde cholangiopancreatography. DPDS was defined as a disconnected PD presenting with R-PFC, PC-Fistulae, or DPDS-P. The primary outcome was NODAP, defined as diabetes mellitus (DM) occurring >3 months after NP. Cox proportional hazards regression was used to evaluate the relationship between DPDS and NODAP. RESULTS: Of 171 patients with NP in this study, the mean clinical follow-up was 46 ± 18 months and the imaging follow-up was 38 ± 20 months. Twenty-seven patients (16%) developed DPDS-P at a median of 28 months. New-onset DM occurred in 54 of the 148 patients (36%), with 22% developing DM within 3 months of NP and 14% developing NODAP at a median of 31 months after AP. DPDS-P was associated with NODAP when compared with non-DPDS patients (adjusted hazard ratio 5.63 95% confidence interval: 1.69–18.74, P = 0.005) while R-PFCs and PC-Fistulae were not. DISCUSSION: DPDS and NODAP occurred in 28% and 14% of the patients, respectively. Pancreatitis of the disconnected pancreas occurred in 16% of the patients and was associated with higher rates of NODAP when compared with patients with other manifestations of DPDS and patients without DPDS.
dc.format.extent9 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartClinical and Translational Gastroenterology, Vol. 13
dc.relation.isreferencedbyLippincott, Williams & Wilkins
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleDisconnected Pancreatic Duct Syndrome: Pancreatitis of the Disconnected Pancreas and Its Role in the Development of Diabetes Mellitus
dc.typeText
dc.type.genreJournal article
dc.description.departmentMedicine
dc.relation.doihttp://dx.doi.org/10.14309/ctg.0000000000000457
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorForde, Kimberly A.
refterms.dateFOA2023-12-21T19:37:02Z


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