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dc.creatorZhou, Yilun
dc.creatorWu, Yu
dc.creatorPan, Yuesong
dc.creatorLi, Hao
dc.creatorYan, Hongyi
dc.creatorMeng, Xia
dc.creatorLin, Jinxi
dc.creatorWang, Hong
dc.creatorMatsushita, Kunihiro
dc.creatorWang, Yongjun
dc.identifier.citationYilun Zhou, Yu Wu, Yuesong Pan, Hao Li, Hongyi Yan, Xia Meng, Jinxi Lin, Hong Wang, Kunihiro Matsushita, Yongjun Wang; Association of Urine Albumin-Creatinine Ratio and Cystatin C-Based Estimated GFR with Outcomes in Patients with Ischemic Stroke. Kidney Blood Press Res 12 May 2022; 47 (5): 320–328.
dc.description.abstractBackground/Aims: Data about the independent and combined effects of cystatin C-based estimated glomerular filtration rate (eGFRcys) and albuminuria on the risk of poor outcome in stroke patients are limited. The aim was to elucidate how these two renal markers affect the clinical outcomes after ischemic stroke separately and jointly. Methods: The study subjects consisted of 10,197 patients with ischemic stroke from the third China National Stroke Registry. The study outcomes were all-cause mortality, poststroke disability, recurrence of stroke, and cardiocerebral vascular disease (CVD) composite events. Cox proportional hazard models and multivariable logistic regression model were applied to evaluate the effects of eGFRcys and urine albumin-creatinine ratio (ACR) on these outcomes. Results: Both reduced eGFRcys and increased ACR were independently associated with higher incidences of all-cause death and poststroke disability (p < 0.01). Mildly decreased eGFRcys (60–89 mL/min/1.73 m2) is associated with increased risk of all-cause death and poststroke disability in the presence of high-normal ACR (10–29 mg/g). Patients with both eGFRcys <45 mL/min/1.73 m2 and ACR ≥30 mg/g at baseline had a 6.8-fold risk for all-cause mortality and 3.6-fold risk for poststroke disability, compared with patients with eGFRcys of 90–119 mL/min/1.73 m2 and ACR <10 mg/g. In addition, increased ACR was associated with recurrent stroke and CVD composite event, while reduced eGFRcys showed no relationship with these outcomes. Conclusions: Both decreased eGFRcys and albuminuria are independent risk factors for all-cause death and poststroke disability. Combining the two markers is useful for improving risk stratification even in those without chronic kidney disease.
dc.format.extent9 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartKidney and Blood Pressure Research, Vol. 47, Iss. 5
dc.relation.isreferencedbyKarger Publishers
dc.rightsAttribution-NonCommercial CC BY-NC
dc.subjectUrine albumin-creatinine ratio
dc.subjectCystatin C-based estimated GFR
dc.subjectIschemic stroke
dc.titleAssociation of Urine Albumin-Creatinine Ratio and Cystatin C-Based Estimated GFR with Outcomes in Patients with Ischemic Stroke
dc.type.genreJournal article
dc.contributor.groupCenter for Metabolic Disease Research (Temple University)
dc.description.departmentMicrobiology, Immunology and Inflammation
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorWang, Hong

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