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dc.creatorLee, Rachael A.
dc.creatorGoldman, Jason
dc.creatorHaidar, Ghady
dc.creatorLewis, Jessica
dc.creatorArif, Sana
dc.creatorHand, Jonathan
dc.creatorLa Hoz, Ricardo M.
dc.creatorPouch, Stephanie
dc.creatorHoladay, Eric
dc.creatorClauss, Heather
dc.creatorKaye, Keith S.
dc.creatorNellore, Anoma
dc.date.accessioned2023-12-21T18:33:36Z
dc.date.available2023-12-21T18:33:36Z
dc.date.issued2022-01-22
dc.identifier.citationRachael A Lee, Jason Goldman, Ghady Haidar, Jessica Lewis, Sana Arif, Jonathan Hand, Ricardo M La Hoz, Stephanie Pouch, Eric Holaday, Heather Clauss, Keith S Kaye, Anoma Nellore, Daptomycin-Resistant Enterococcus Bacteremia Is Associated With Prior Daptomycin Use and Increased Mortality After Liver Transplantation, Open Forum Infectious Diseases, Volume 9, Issue 3, March 2022, ofab659, https://doi.org/10.1093/ofid/ofab659
dc.identifier.issn2328-8957
dc.identifier.urihttp://hdl.handle.net/20.500.12613/9311
dc.description.abstractBackground. Risk factors for acquisition of vancomycin-resistant Enterococcus (VRE) include immunosuppression, antibiotic exposure, indwelling catheters, and manipulation of the gastrointestinal tract, all of which occur in liver transplant recipients. VRE infections are documented in liver transplantation (LT); however, only one single center study has assessed the impact of daptomycin-resistant Enterococcus (DRE) in this patient population. Methods. We conducted a retrospective multicenter cohort study comparing liver transplant recipients with either VRE or DRE bacteremia. The primary outcome was death within 1 year of transplantation. Multivariable logistic regression analyses were performed to calculate adjusted odds ratios for outcomes of interest. Results. We identified 139 cases of Enterococcus bacteremia following LT, of which 78% were VRE and 22% were DRE. When adjusted for total intensive care unit days in the first transplant year, liver-kidney transplantation, and calcineurin inhibitor use, patients with DRE bacteremia were 2.65 times more likely to die within 1 year of transplantation (adjusted odds ratio [aOR], 2.648; 95% CI, 1.025–6.840; P = .044). Prior daptomycin exposure was found to be an independent predictor of DRE bacteremia (aOR, 30.62; 95% CI, 10.087–92.955; P < .001). Conclusions. In this multicenter study of LT recipients with Enterococcus bacteremia, DRE bacteremia was associated with higher 1-year mortality rates when compared with VRE bacteremia. Our data provide strong support for dedicated infection prevention and antimicrobial stewardship efforts for transplant patients. Further research is needed to support the development of better antibiotics for DRE and practical guidance focusing on identification and prevention of colonization and subsequent infection in liver transplant recipients at high risk for DRE bacteremia.
dc.format.extent7 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartOpen Forum Infectious Diseases, Vol. 9, Iss. 3
dc.relation.isreferencedbyOxford University Press (OUP)
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBacteremia
dc.subjectDaptomycin
dc.subjectEnterococcus
dc.subjectLiver transplant
dc.titleDaptomycin-Resistant Enterococcus Bacteremia Is Associated With Prior Daptomycin Use and Increased Mortality After Liver Transplantation
dc.typeText
dc.type.genreJournal article
dc.description.departmentMedicine
dc.relation.doihttp://dx.doi.org/10.1093/ofid/ofab659
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorHoladay, Eric
dc.temple.creatorClauss, Heather
refterms.dateFOA2023-12-21T18:33:36Z


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