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dc.creatorGeynisman, Daniel
dc.creatorHandorf, Elizabeth
dc.creatorWong, Yu-Ning
dc.creatorDoyle, Jamie
dc.creatorPlimack, Elizabeth
dc.creatorHorwitz, Eric M.
dc.creatorCanter, Daniel J.
dc.creatorUzzo, Robert
dc.creatorKutikov, Alexander
dc.creatorSmaldone, Marc C.
dc.identifier.citationCancer Medicine 2016; 5( 2): 192– 199
dc.description.abstractTo describe the clinical characteristics, treatment patterns and outcomes in advanced small cell bladder cancer (aSCBC) patients and compare to those with urothelial carcinoma (UC). Individuals in the National Cancer Data Base with a diagnosis of either nodal (TxN+M0) or distant metastatic (TxNxM1) disease were identified from 1998 to 2010. We assessed the relationships between stage, treatment modalities and survival in the aSCBC cohort and compared these to UC patients. In the 960 patient aSCBC cohort (62% M1), 50% received palliative therapy alone, 68% in M1 versus 21% in M0 groups (P < 0.0001). Single modality local therapy (15%) and surgical (21%) or radiation-based (14%) multimodal therapy (MMT) were used in the other 50%. Cystectomy-based MMT was utilized in 45% of N+M0 versus 6.4% of NxM1 patients (P < 0.0001). Median overall survival (OS) for aSCBC patients was 8.6 months; 13.0 months in N+M0 versus 5.3 months in NxM1 patients (P < 0.0001). Survival was similar between TxN1M0 and TxN2-3M0 patients (14.8 months vs. 12.1 months, P = 0.15). Urothelial carcinoma patients (n = 27,796, 45% M1) lived longer compared to aSCBC patients in the N+M0 group (17.3 months vs. 13.0 months, P = 0.0007). There were not clinically significant differences in OS between UC and aSCBC patients in the M1 group. Advanced SCBC is a rare disease with a poor survival and palliative therapy is common, especially in M1 patients. In comparison to UC, the outcomes for aSCBC patients are worse in those with lymph node only involvement but similar in those with distant disease.
dc.format.extent8 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartCancer Medicine, Vol. 5, Iss. 2
dc.relation.isreferencedbyWiley Open Access
dc.rightsAttribution CC BY
dc.subjectBladder cancer
dc.subjectSmall cell bladder cancer
dc.subjectTreatment patterns
dc.subjectUrothelial carcinoma
dc.titleAdvanced small cell carcinoma of the bladder: clinical characteristics, treatment patterns and outcomes in 960 patients and comparison with urothelial carcinoma
dc.type.genreJournal article
dc.contributor.groupFox Chase Cancer Center (Temple University)
dc.description.departmentMedical Oncology
dc.description.departmentBiostatistics and Bioinformatics
dc.description.departmentRadiation Oncology
dc.description.departmentSurgical Oncology
dc.description.departmentUrologic Oncology
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorGeynisman, Daniel M.
dc.temple.creatorHandorf, Elizabeth
dc.temple.creatorWong, Yu-Ning
dc.temple.creatorDoyle, Jamie
dc.temple.creatorPlimack, Elizabeth R.
dc.temple.creatorHorwitz, Eric M.
dc.temple.creatorCanter, Daniel J.
dc.temple.creatorUzzo, Robert G.
dc.temple.creatorKutikov, Alexander
dc.temple.creatorSmaldone, Marc C.

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