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dc.creatorKeefe, Kathleen M.
dc.creatorSheikh, Imran S.
dc.creatorSmith, George M.
dc.date.accessioned2023-06-22T15:11:39Z
dc.date.available2023-06-22T15:11:39Z
dc.date.issued2017-03-03
dc.identifier.citationKeefe KM, Sheikh IS, Smith GM. Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury. International Journal of Molecular Sciences. 2017; 18(3):548. https://doi.org/10.3390/ijms18030548
dc.identifier.issn1422-0067
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8753
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8789
dc.description.abstractNeurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and neurotransmitter release, and elicit the plasticity and growth of axons within the adult central and peripheral nervous system. Since the 1950s, these factors have been extensively studied in traumatic injury models. Here we review several members of the classical family of neurotrophins, the receptors they bind to, and their contribution to axonal regeneration and sprouting of sensory and motor pathways after spinal cord injury (SCI). We focus on nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3), and their effects on populations of neurons within diverse spinal tracts. Understanding the cellular targets of neurotrophins and the responsiveness of specific neuronal populations will allow for the most efficient treatment strategies in the injured spinal cord.
dc.format.extent17 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartInternational Journal of Molecular Sciences, Vol. 18, Iss. 3, Special issue: Neurotrophic Factors - Historical Perspective and New Directions
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSpinal cord injury
dc.subjectNeurotrophic factors
dc.subjectNerve growth factor
dc.subjectBrain-derived neurotrophic factor
dc.subjectNeurotrophin-3
dc.subjectNeuroprotection
dc.subjectPlasticity
dc.subjectRegeneration
dc.titleTargeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury
dc.typeText
dc.type.genreJournal article
dc.contributor.groupShriners Hospital Pediatric Research Center, Center for Neural Repair and Rehabilitation (Temple University)
dc.relation.doihttps://doi.org/10.3390/ijms18030548
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorKeefe, Kathleen M.
dc.temple.creatorSheikh, Imran S.
dc.temple.creatorSmith, George M.
refterms.dateFOA2023-06-22T15:11:39Z


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