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dc.creatorPerry, Blair W.
dc.creatorCard, Daren C.
dc.creatorMcGlothlin, Joel W.
dc.creatorPasquesi, Giulia I. M.
dc.creatorAdams, Richard H.
dc.creatorSchield, Drew R.
dc.creatorHales, Nicole R.
dc.creatorCorbin, Andrew B.
dc.creatorDemuth, Jeffrey P.
dc.creatorHoffmann, Federico G.
dc.creatorVandewege, Michael W.
dc.creatorSchott, Ryan K.
dc.creatorBhattacharyya, Nihar
dc.creatorChang, Belinda S. W.
dc.creatorCasewell, Nicholas R.
dc.creatorWhiteley, Gareth
dc.creatorReyes-Velasco, Jacobo
dc.creatorMackessy, Stephen P.
dc.creatorGamble, Tony
dc.creatorStorey, Kenneth B.
dc.creatorBiggar, Kyle K.
dc.creatorPassow, Courtney N.
dc.creatorKuo, Chih-Horng
dc.creatorMcGaugh, Suzanne E.
dc.creatorBronikowski, Anne M.
dc.creatorde Koning, A. P. Jason
dc.creatorEdwards, Scott V.
dc.creatorPfrender, Michael E.
dc.creatorMinx, Patrick
dc.creatorBrodie, Edmund D., Jr.
dc.creatorBrodie, Edmund D., Jr.
dc.creatorWarren, Wesley C.
dc.creatorCastoe, Todd A.
dc.date.accessioned2023-06-22T15:11:30Z
dc.date.available2023-06-22T15:11:30Z
dc.date.issued2018-07-30
dc.identifier.citationBlair W Perry, Daren C Card, Joel W McGlothlin, Giulia I M Pasquesi, Richard H Adams, Drew R Schield, Nicole R Hales, Andrew B Corbin, Jeffery P Demuth, Federico G Hoffmann, Michael W Vandewege, Ryan K Schott, Nihar Bhattacharyya, Belinda S W Chang, Nicholas R Casewell, Gareth Whiteley, Jacobo Reyes-Velasco, Stephen P Mackessy, Tony Gamble, Kenneth B Storey, Kyle K Biggar, Courtney N Passow, Chih-Horng Kuo, Suzanne E McGaugh, Anne M Bronikowski, A P Jason de Koning, Scott V Edwards, Michael E Pfrender, Patrick Minx, Edmund D Brodie, III, Edmund D Brodie, Jr, Wesley C Warren, Todd A Castoe, Molecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome, Genome Biology and Evolution, Volume 10, Issue 8, August 2018, Pages 2110–2129, https://doi.org/10.1093/gbe/evy157
dc.identifier.issn1759-6653
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8718
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8754
dc.description.abstractColubridae represents the most phenotypically diverse and speciose family of snakes, yet no well-assembled and annotated genome exists for this lineage. Here, we report and analyze the genome of the garter snake, Thamnophis sirtalis, a colubrid snake that is an important model species for research in evolutionary biology, physiology, genomics, behavior, and the evolution of toxin resistance. Using the garter snake genome, we show how snakes have evolved numerous adaptations for sensing and securing prey, and identify features of snake genome structure that provide insight into the evolution of amniote genomes. Analyses of the garter snake and other squamate reptile genomes highlight shifts in repeat element abundance and expansion within snakes, uncover evidence of genes under positive selection, and provide revised neutral substitution rate estimates for squamates. Our identification of Z and W sex chromosome-specific scaffolds provides evidence for multiple origins of sex chromosome systems in snakes and demonstrates the value of this genome for studying sex chromosome evolution. Analysis of gene duplication and loss in visual and olfactory gene families supports a dim-light ancestral condition in snakes and indicates that olfactory receptor repertoires underwent an expansion early in snake evolution. Additionally, we provide some of the first links between secreted venom proteins, the genes that encode them, and their evolutionary origins in a rear-fanged colubrid snake, together with new genomic insight into the coevolutionary arms race between garter snakes and highly toxic newt prey that led to toxin resistance in garter snakes.
dc.format.extent20 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartGenome Biology and Evolution, Vol. 10, Iss. 8
dc.relation.isreferencedbyOxford University Press
dc.rightsAttribution-NonCommercial CC BY-NC
dc.rights.urihttp://www.creativecommons.org/licenses/by-nc/4.0/
dc.subjectThamnophis sirtalis
dc.subjectCo-evolution
dc.subjectVenom
dc.subjectVision
dc.subjectSex chromosomes
dc.titleMolecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome
dc.typeText
dc.type.genreJournal article
dc.contributor.groupInstitute for Genomics and Evolutionary Medicine (Temple University)
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.1093/gbe/evy157
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.temple.creatorVandewege, Michael W.
refterms.dateFOA2023-06-22T15:11:30Z


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